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Intracellular calcium-binding protein, with cell adhesion and vascular regulatory actions; found in the endoplasmic reticulum.
[calcium + (endoplasmic and cytoplasmic) reticula + -in]
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Type 1 vs type 2 calreticulin mutations in primary myelofibrosis: differences in phenotype and prognostic impact.
Hensler et al., "Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients," Blood, vol.
Timchenko et al., "Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate," The EMBO Journal, vol.
Melatonin may also interact with cytosolic proteins including calmodulin and calreticulin, which are involved in the cytoskeleton regulation and control of nuclear receptors, respectively [7, 62, 63].
Endoplasmic reticulum proteins (ERps) play critical roles in ERS and many proteins such as ERp29, ERp72, and calreticulin identified to be ERS concerning [5-8].
In 5-10% of patients the thrombopoietin receptor (MPL) gene is impaired, while in 30-45% of patients no specific molecular marker had been described until the discovery of calreticulin (CALR).
(2007) Adiponectin modulates inflammatory reactions via calreticulin receptor--dependent clearance of early apoptotic bodies.
To investigate whether CA induces ER stress in GBM cells we evaluated the expression of calreticulin (CALR) and heat shock protein 70 (HSP70) after exposure to CA by immunoblot analysis.
The effector proteins include CLAVATA3 (CLV3) /ESR (CLE) -like (Wang et al., 2005; Patel et al., 2008; Lu et al., 2009; Wang et al., 2010a; Wang et al., 2010b), SPRY domain-containing (SPRYSEC) effector proteins (Huang et al., 2006; Rehman et al., 2009; Sacco et al., 2009; Postma et al., 2012), Mi-EFF1 (Jaouannet et al., 2012), calreticulin Mi-CRT (Jaubert et al., 2002; Jaubert et al., 2005; Jaouannet et al., 2013), and Hs19C07 (Lee et al., 2011).
Cellular functions of endoplasmic reticulum chaperones calreticulin, calnexin, and ERp57.
Expression patterns of calreticulin from bombyx mori after immune challenge.
The largest number of proteins were associated with the cytoplasm, including histone proteins, citrate synthase, elongation-factor-1-[alpha], cyclophilin, calreticulin, luminal-binding protein 4, a probable glycerophosphoryl diester phosphodiesterase, polyubiquitin, peptidyl-prolyl cis-trans isomerase, BIP isoform A, and granule bound starch synthase.