In the latest study, 27 men followed a calorie restricted diet
for 12 weeks, while the other study looked at short-term effects of protein on hunger/appetite in 13 men fed controlled meals on four separate days.
While an earlier published rodent study showed that ultra-high doses of resveratrol (1565 milligram human dose - equivalent to 1500 bottles of wine or many dietary supplement capsules) successfully overcame the adverse effects of a high-fat diet, the lowest dose that genetically mimics a calorie restricted diet
was, until now, undetermined.
Editor's note: Getting adequate sleep may be beneficial when trying to follow a low-calorie or calorie restricted diet
The project is focused on identifying a robust panel of genes in adipose tissue (fat) that are regulated by a calorie restricted diet
The Company's research found that variations within the Perilipin genes are associated with resistance to body weight and fat loss in overweight study subjects who were provided a calorie restricted diet
The findings also revealed that people following the Mediterranean diet also showed a greater adherence to the calorie restricted diet
, an increase in physical activity and a greater decrease in abdominal fat.
In a head-to-head comparison, a unique patent-applied-for matrix of molecules (resveratrol, quercetin, IP6 rice bran) as provided in Longevinex(R) activated 9-fold more longevity genes (1711) than plain resveratrol (225 genes) or a calorie restricted diet
(198 genes) at a dose of resveratrol 17-320 times lower than prior studies.
In a study presented at the European Congress on Obesity, scientists found that overweight or obese people who regularly used the equipment in combination with a calorie restricted diet
were more successful at long-term weight loss and shedding the fat around their abdominal organs than those who combined dieting with a more conventional fitness routine.
Resveratrol, a molecule found in red wine, has been touted as a molecular mimic of a calorie restricted diet
, an intervention that has been shown to nearly double the lifespan of all forms of life when caloric intake is cut in half.
Mouse longevity studies take about 3-4 years and cost more than a million dollars, so more economical gene array studies are performed and compared against a calorie restricted diet
, which is a known intervention that prolongs life in all life forms.
Only the nutriceutical matrix, and not resveratrol or a long-term calorie restricted diet
, upregulated the Foxo1 gene which enters the cell nucleus and promotes the expression of key longevity genes.
In a study of obese patients on a calorie restricted diet
, those with one perilipin genetic pattern were resistant to weight loss over a 12 month period.