As noted above, one of the best known features of the AGCT is the famous Call-Exner body and anytime pathologists see small acini reminiscent of such a structure, that they might be Call-Exner bodies comes not unreasonably to mind, and this happens with diverse neoplasms including endometrioid carcinomas with microacini as well as monodermal teratomas such as struma ovarii and carcinoid.
E, Classic Call-Exner bodies. F, Prominent pseudopapillary pattern.
Histologic characteristics such as nuclear grooves and Call-Exner bodies
of granulosa cell tumor are important clues in the differential diagnosis.
Whereas adult GCTs comprise diffuse cords or trabeculae and small follicles termed Call-Exner bodies
of rounded cells with scant cytoplasm and pale "coffee-bean" nuclei, juvenile GCTs have nuclei that are rounded, hyperchromatic with moderate to abundant eosinophilic or vacuolated cytoplasm.
They infiltrated through the interstitium as nests, cords, and single cells, with focal rosetting, reminiscent of Call-Exner bodies
. The immunohistochemical profile (coexpression of vimentin, inhibin, scattered cytokeratin, and CD56) was consistent with testicular GCT (Figure 2).
Louise Call, who gave her name to the Call-Exner bodies
found in granulosa cell tumours, is remembered in an article in this issue.
Histopathology report revealed large ovoid cells with moderate to high atypia and scanty cytoplasm, Call-Exner bodies
present, few cells with coffee bean nucleolus seen.
are characteristic of GCT and appear in 30% to 60% of cases.
Call-Exner bodies is the name given to small follicular structures seen in granulosa cell tumours (GCTs), as they resemble the immature follicles first described by Call and Exner in the ovaries of rabbits in 1875.
Call-Exner bodies are the hallmark of GCTs, occurring in 30 60% of cases.
The microfollicular pattern was characterized by the presence of numerous cavities simulating Call-Exner bodies
. These cavities contained eosinophilic fluid and sometimes hyalinized basement membrane material.
appear in 90% of granulosa cell tumours.