289, yielded a novel mammalian virus from the family Caliciviridae that we further characterized by near full-length genome sequencing using random amplification with next-generation sequencing, specific reverse transcription PCRs, and 3' rapid amplification of cDNAends PCR (Figure 1, panel A) as described (6,7).
The Caliciviridae genome encodes a polyprotein precursor for nonstructural proteins, and 2 structural capsid proteins, viral protein (VP) 1 and VP2, from 2 or 3 open reading frames (ORFs) (Figure 1, panel B) (8,9).
Although no species demarcation criteria have been defined for the family Caliciviridae by the International Committee on the Taxonomy of Viruses, we classified calicivirus Bangladesh/289/2007 in the proposed genus Recovirus, primarily on the basis of phylogenetic analyses (5).
Characterization of a rhesus monkey calicivirus representing a new genus of Caliciviridae. J Virol.
Viruses in the family Caliciviridae are nonenveloped, polyadenylated, single-stranded, positive-sense RNA viruses (1).
Complete genomes of strains representing different Caliciviridae genera were selected for a phylogenetic tree (Figure 1).
In the Caliciviridae family, genogroup III noroviruses (NoVsGIII) and neboviruses are associated with enteric disease in cattle (1), while genogroups I and II noroviruses (NoVsGI, NoVsGII) are a major cause of viral gastroenteritis in humans.
Given the capsid analyses, the new Nebovirus genus in the Caliciviridae family should thus comprise 2 genotypes: one would include the reference strains Bo/Nebraska/80/US and Bo/Newbury1/76/UK and the second would include Bo/DijonA216/06/FR.
Genomic characterization of the unclassified bovine enteric virus Newbury agent-1 (Newbury1) endorses a new genus in the family Caliciviridae. Virology.
ICTV currently recognizes 2 species, Rabbit hemorrhagic disease virus and European brown hare syndrome virus, in the genus Lagovirus, family Caliciviridae
. ICTV does not make policies for designation or recognition of strains or variants of viruses within a species.
NoVs are genetically heterogeneous viruses that belong to the family Caliciviridae
. The viral capsid encloses a single-stranded, positive-sense RNA genome of 7.3-7.7 kb that is organized in 3 open reading frames (ORFs), of which ORF1 encodes a polyprotein that is proteolytically cleaved into 6 nonstructural proteins, including RNA-dependent RNA polymerase (RdRp), helicase, and protease (1).
Noroviruses are members of the family Caliciviridae
and recognized as major pathogens in outbreaks of gastroenteritis worldwide.