edetate calcium disodium

(redirected from Calcium Disodium Versenate)

ed·e·tate cal·ci·um di·so·di·um

(ed'ă-tāt kal'sē-ŭm dī-sō'dē-ŭm),
Contracted name for a salt of ethylenediaminetetraacetate, an agent used as a chelator of lead and some other heavy metals. Available in several forms: disodium, sodium, and trisodium.

edetate calcium disodium

A chelating agent capable of reducing poisonous levels of heavy metals, such as lead, manganese and iron, in the body. It has the advantage over edetate sodium that it has a lower affinity for calcium than for these heavier metals. It does not, however, remove mercury.

Edetate calcium disodium (EDTA calcium)

A chemical agent used to remove excess lead from the body.
Mentioned in: Lead Poisoning
References in periodicals archive ?
Valeant has increased the price of Calcium Disodium Versenate by over 2,700 percent since it acquired the drug as part of its purchase of Medicis in 2013.
Baum, CEO of Imprimis, stated, "Consistent with our commitment to take care of patients, particularly those who are most vulnerable in our country, we are pleased to offer a lower-cost alternative to Valeant's Calcium Disodium Versenate, which has seen serious price increases, particularly after the lead poisoning tragedy in Flint, Michigan.
Initial therapy included parenteral enrofloxacin (15 mg/kg IM q12h, Baytril, Bayer Healthcare LLC, Shawnee Mission, KS, USA) for possible bacterial gastroenteritis caused by foreign material, subcutaneous lactated Ringer's (50 mL/kg divided q12h), calcium disodium versenate (a) (25 mg/kg diluted in 0.9% NaCl, SC q 12h) for metal chelation (pending results of the blood lead analysis), butorphanol for analgesia (1 mg/kg IM qSh; Torbugesic, Fort Dodge Animal Health, Fort Dodge, IA, USA), and 1 dose of iron dextran for anemia (10 mg/kg IM).
(7,8) On the basis of the presence of wires in the GI tract and the possibility of other toxic metals, the bird was placed on parenteral chelation therapy (calcium disodium versenate) while hospitalized for 5 days and then orally at home using DMSA for 7 days.
The boy was treated with 5 days of British antilewisite (dimercaprol) and calcium disodium versenate, and he clinically responded, Dr.
Initial emergency stabilization treatment included the administration of diazepam (0.5 mg/kg IM); calcium glubionate (100 mg/kg PO); calcium gluconate (100 mg/kg IM); supplemental fluids (45 mL/kg SC; Normosol-R, Hospira, Inc, Lake Forest, IL, USA); doxycycline (60 mg/kg IM; Vibravenos formulation, Pfizer Laboratories, London, Ontario, Canada); vitamins A, D, and E (3300 IU/kg IM; Northwest Pharmacy and Compounding Center, Houston, TX, USA); and edetate calcium disodium (35 mg/kg IM; calcium disodium versenate, 3M Pharmaceuticals, Northridge, CA, USA).
The boy was treated with dimercaprol (i.e., BAL) followed by calcium disodium versenate (i.e., EDTA), and his BLL decreased to 57 [micro]g/dL.