Valeant has increased the price of Calcium Disodium Versenate by over 2,700 percent since it acquired the drug as part of its purchase of Medicis in 2013.
Baum, CEO of Imprimis, stated, "Consistent with our commitment to take care of patients, particularly those who are most vulnerable in our country, we are pleased to offer a lower-cost alternative to Valeant's Calcium Disodium Versenate, which has seen serious price increases, particularly after the lead poisoning tragedy in Flint, Michigan.
Initial therapy included parenteral enrofloxacin (15 mg/kg IM q12h, Baytril, Bayer Healthcare LLC, Shawnee Mission, KS, USA) for possible bacterial gastroenteritis caused by foreign material, subcutaneous lactated Ringer's (50 mL/kg divided q12h), calcium disodium versenate (a) (25 mg/kg diluted in 0.9% NaCl, SC q 12h) for metal chelation (pending results of the blood lead analysis), butorphanol for analgesia (1 mg/kg IM qSh; Torbugesic, Fort Dodge Animal Health, Fort Dodge, IA, USA), and 1 dose of iron dextran for anemia (10 mg/kg IM).
(7,8) On the basis of the presence of wires in the GI tract and the possibility of other toxic metals, the bird was placed on parenteral chelation therapy (calcium disodium versenate) while hospitalized for 5 days and then orally at home using DMSA for 7 days.
The boy was treated with 5 days of British antilewisite (dimercaprol) and calcium disodium versenate
, and he clinically responded, Dr.
Initial emergency stabilization treatment included the administration of diazepam (0.5 mg/kg IM); calcium glubionate (100 mg/kg PO); calcium gluconate (100 mg/kg IM); supplemental fluids (45 mL/kg SC; Normosol-R, Hospira, Inc, Lake Forest, IL, USA); doxycycline (60 mg/kg IM; Vibravenos formulation, Pfizer Laboratories, London, Ontario, Canada); vitamins A, D, and E (3300 IU/kg IM; Northwest Pharmacy and Compounding Center, Houston, TX, USA); and edetate calcium disodium (35 mg/kg IM; calcium disodium versenate
, 3M Pharmaceuticals, Northridge, CA, USA).
The boy was treated with dimercaprol (i.e., BAL) followed by calcium disodium versenate
(i.e., EDTA), and his BLL decreased to 57 [micro]g/dL.