calcitriol


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calcitriol

 [kal´sĭ-tri´ol]
1,25-dihydroxycholecalciferol; a form of vitamin D used as a calcium regulator in the management of hypocalcemia in conditions such as rickets, osteodystrophy, hypoparathyroidism, and complications of renal dialysis; administered orally or intravenously.

cal·ci·tri·ol

(kal'si-trī'ol),
1α,25-Dihydroxycholecalciferol (thus, a 1,3,25-triol); formation of calcitriol is the second step in the biologic conversion of vitamin D3 to its active form; it is more potent than calcidiol.

calcitriol

A form of vitamin D3 which promotes intestinal absorption of Ca2+, increases renal tubular reabsorption of Ca2+ and reduces Ca2+ resorption by bone.
 
Indications
Postmenopausal and corticosteroid-induced osteoporosis, hypocalcaemia, hypoparathyroidism, osteomalacia, rickets, renal osteodystrophy, chronic renal dialysis.

Adverse effects
Nausea, vomiting, constipation, anorexia, headache, thirst, sweating, polyuria—all due to hypercalcaemia.

calcitriol

A vitamin D analogue drug used in the treatment of low calcium levels resulting from kidney disease. Brand names are Calcijex, Rocatrol and Silkis.
References in periodicals archive ?
One patient was previously followed for hypophosphatemic rickets and treated with calcitriol and phosphate.
These are available as vitamin D analogues (e.g., calcitriol, calcifediol, doxercalciferol, and paricalcitol) and come under pregnancy drug category C.
Un metaanalisis demostro que la administracion profilactica de 3600 mg de carbonato de calcio y 0,5 mcg de calcitriol durante los 10-15 dias posoperatorios, disminuye la frecuencia de sintomas de hipocalcemia de 35% a 3% (51).
To investigate the presence or absence of an interaction between budesonide and calcitriol, the 2 x 2 factorial experimental design was used.
Further, our patient was unique and challenging to manage due to requirement of high doses of calcium, calcitriol, and Vitamin D.
Consistent with our findings, = a high risk of hypocalcaemia in patients with CKD is noted; however with aggressive calcium and calcitriol supplementation, use of high calcium dialysate, and weekly blood tests monitoring calcium in the first month of initiating denosumab, none of the patients needed inpatient admission for management of hypocalcaemia.
We have then tried to establish a tumorgraft model from freshly collected breast cancer samples in nude mice to study calcitriol effects.
To examine concentration-dependent effects, three concentrations (10, 100, and 1000 nM) of calcitriol were added to both NP and HP media.
Antiproliferative effects of calcitriol in B cells such as proliferation, initiation of apoptosis, decreased immunoglobulin production and inhibition of differentiation, were earlier considered to be exclusively indirectly mediated by T helper (Th) cells.
tuberculosis infection to decrease calcitriol synthesis and directly lower blood calcium levels.
The treatment with topical fluticasone propionate 0.05% and topical calcitriol ointment with 0.5 mg/kg of prednisolone daily for 6 weeks with close monitoring.
Dysregulated calcitriol production is a very rare occurrence in patients with hypercalcemia associated with solid tumors, where suppressed serum calcitriol levels are characteristic.

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