cadherin

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cad·her·in

(kad-hēr'-in),
One of a class of integral-membrane glycoproteins that has a role in cell-cell adhesion and is important in morphogenesis and differentiation; E-cadherin is also known as uvomorulin and is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells. All are calcium-binding proteins.
[cell + adhere + -in]
Farlex Partner Medical Dictionary © Farlex 2012

cadherin

(kăd-hîr′ĭn)
n.
Any of a group of proteins that span the plasma membrane of eukaryotic cells and, in the presence of calcium, bind to identical proteins in adjacent cells, thus linking cells together in tissues.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

cad·her·in

(kad-hēr'in)
One of a class of integral-membrane glycoproteins that has a role in cell-to-cell adhesion and is important in morphogenesis and differentiation; E-cadherin (also known as uvomorulin) is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cadherin

one of a family of GLYCOPROTEINS that are involved in cell to cell attachment for preserving the integrity of all solid tissues. Cadherins have three major regions: the extracellular region that mediates ADHESION (cadherin to cadherin) for cell to cell binding; the transmembrane region; and the cytoplasmic region that extends into the cell and interacts with CATENINS, which in turn are linked to the ACTIN of the CYTOSKELETON. Loss of cadherin binding correlates with the invasion of CANCER.

Cadherins also effect tissue formation by modifying their binding strength to allow cell sorting and migration.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005