Cache Valley virus

A negative-sense, single-stranded RNA virus of the Bunyaviridae family, genus Orthobunyavirus, Bunyamwera virus group serotype, which was first isolated in Utah and has been found in the rest of the US, especially the Midwest. It is mosquito-borne and causes outbreaks of spontaneous abortion, congenital malformations—e.g., musculoskeletal and CNS defects in sheep during lambing season. It may rarely infect humans, causing severe encephalitis and multiorgan failure.

Vector
Mosquitos—genera Culiseta, Aedes, Anopheles.

Cache Valley virus

Virology A common Bunyamwera virus, isolated in Utah in 1956 and recovered primarily from mosquitos–genera Culiseta, Aedes, Anopheles, and occasionally from vertebrates; in livestock, CVS may cause congenital malformations–musculoskeletal and CNS defects Clinical Rare in humans; CVS infection may be linked to severe encephalitis and multiorgan failure. See Bunyavirus, Encephalitis.

Cache Valley virus

one of the California serotype bunyaviruses associated with equine viral encephalomyelitis.

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References in periodicals archive ?

Furthermore, MAGV is considered a subtype of Cache Valley virus (CVV), which sometimes causes symptomatic human infection (7-9), reinforcing lingering concerns about the possible pathogenicity of MAGV for humans.

Cache valley virus in a patient diagnosed with aseptic meningitis.

Maguari virus associated with human disease

Louis encephalitis (23), Jamestown Canyon virus (11), Powassan virus (seven), eastern equine encephalitis virus (six), unspecific California serogroup virus (four), and Cache Valley virus (one).

One case of Cache Valley virus disease was reported from Missouri.

West Nile virus and other nationally notifiable arboviral diseases--United States, 2015

Serological evidence of California group and Cache Valley virus infection in Minnesota white-tailed deer.

Severe sepsis caused by California serogroup orthobunyavirus

Cache Valley virus and California serogroup viruses) are distantly related and have [approximately equal to] 11% amino acid sequence homology to SFTSV.

Novel bunyavirus in domestic and captive farmed animals, Minnesota, USA

The virus was found to belong to the Bunyamwera serogroup (genus Orthobunyavirus) by ELISA and identified as Cache Valley virus by PCR and sequencing (28).

Cell culture and electron microscopy for identifying viruses in diseases of unknown cause

We previously reported the isolation of Cache Valley virus (CVV), Kairi virus (KRIV), Cholul virus (CHLV), and South River virus (SOURV) from mosquitoes in the Yucatan Peninsula of Mexico (1-3).

Orthobunyavirus antibodies in humans, Yucatan Peninsula, Mexico

Mice exposed to uninfected mosquitoes and injected at the feeding site with Cache Valley virus develop enhanced viremia and seroconversion compared with unbitten mice or to those co-injected with virus and mosquito saliva (20).

Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice.

Venezuelan equine encephalitis virus transmission and effect on pathogenesis

We document the second known case of Cache Valley virus disease in a human.

Second human case of Cache Valley virus disease

In the case of vaccines manufactured in calves, the agents of concern include several bovine viruses (bovine viral diarrhea virus, bovine parainfluenza virus type 3, bovine respiratory syncytial virus, bovine adenoviruses, bovine parvovirus[es], bovine herpesvirus 1 [infectious bovine rhinotracheitis virus], other bovine herpesviruses, bovine reovirus[es], rabies virus, bluetongue viruses, bovine polyoma virus, bovine circovirus, Cache Valley virus, and orthopoxviruses other than vaccinia [such as cowpox]).