Cache Valley virus
(CVV; family Bunyaviridae, genus Orthobunyavirus) is widespread throughout North and Central America and infects many species of domestic ungulates (sheep and cattle), but white-tailed deer are a likely reservoir (1).
Louis encephalitis (23), Jamestown Canyon virus (11), Powassan virus (seven), eastern equine encephalitis virus (six), unspecific California serogroup virus (four), and Cache Valley virus
Other viruses, such as Akabane virus, Rift Valley Fever virus, Cache Valley virus
, Border disease virus, and Wesselsbron disease virus, are also associated with the occurrence of CNS malformations (OBERST, 1993), but these viruses have not yet been diagnosed in cattle in Brazil.
The culprit was an infection of Cache Valley virus
, carried by the mosquito which bit him on his hunt.
Furthermore, MAGV is considered a subtype of Cache Valley virus
(CVV), which sometimes causes symptomatic human infection (7-9), reinforcing lingering concerns about the possible pathogenicity of MAGV for humans.
Serological evidence of California group and Cache Valley virus
infection in Minnesota white-tailed deer.
Other bunyaviruses in North America (e.g., Cache Valley virus
and California serogroup viruses) are distantly related and have [approximately equal to] 11% amino acid sequence homology to SFTSV.
The virus was found to belong to the Bunyamwera serogroup (genus Orthobunyavirus) by ELISA and identified as Cache Valley virus
by PCR and sequencing (28).
We previously reported the isolation of Cache Valley virus
(CVV), Kairi virus (KRIV), Cholul virus (CHLV), and South River virus (SOURV) from mosquitoes in the Yucatan Peninsula of Mexico (1-3).
Mice exposed to uninfected mosquitoes and injected at the feeding site with Cache Valley virus
develop enhanced viremia and seroconversion compared with unbitten mice or to those co-injected with virus and mosquito saliva (20).
We document the second known case of Cache Valley virus
disease in a human.
In the case of vaccines manufactured in calves, the agents of concern include several bovine viruses (bovine viral diarrhea virus, bovine parainfluenza virus type 3, bovine respiratory syncytial virus, bovine adenoviruses, bovine parvovirus[es], bovine herpesvirus 1 [infectious bovine rhinotracheitis virus], other bovine herpesviruses, bovine reovirus[es], rabies virus, bluetongue viruses, bovine polyoma virus, bovine circovirus, Cache Valley virus
, and orthopoxviruses other than vaccinia [such as cowpox]).