The long-term Finnish study by Imtiaz and colleagues and the Cache County study
provide tentative observational data support for a "critical window" hypothesis, leaving open the possibility that initiating systemic HT soon after menopause onset and continuing it long term may reduce the risk of AD.
The Cache County Study
on Memory Health and Aging was initiated in 1994  and consists of 5092 participants representing approximately 90% of the Cache County population aged 65 and older in 1994.
Some research, such as the 2002 Cache County Study
of more than 3,000 people, is very positive and suggests that aspirin and other anti-inflammatory medications could reduce the risk by 23%.
Hayden of Duke University Medical Center, Durham, N.C., based her study on data from the Cache County Study
of Memory, Health, and Aging.
In the Cache County Study
on Memory in Aging, for example, about 20% of AD patients had suffered with depression in the past month (Am.
The research, published in the journal Archives of Neurology, was based on the findings of a large, continuing research project known as the Cache County Study
. Researchers have been tracking 4,740 residents of Cache County, Utah, since 1995 to learn more about dementia.
Heidi Wengreen, Ph.D., described findings from 2,741 men and women participating in the Cache County Study
on Memory, Health, and Aging, a prospective study of residents of Cache Count, Utah, who were 65 years old or older when the study began in 1995.
Wengreen, Ph.D., of Utah State University, Logan, examined compliance with the Dietary Approaches to Stop Hypertension (DASH) eating plan and dementia rates among participants in the Cache County Study
on Memory, Health, and Aging.
The Cache County study
is the only epidemiologic study that sufficiently tests the hypothesis that early estrogen slows the rate of cognitive decline.
Lending support to the relationship between late-life dementia and high blood pressure was a third population-based study, this one of more than 5,000 individuals aged 65 years and older from Cache County, Utah (the Cache County Study
To assess whether protection against AD might be specific to individual classes of antihypertensive drugs, the investigators analyzed data from the Cache County study
, an ongoing investigation of dementias in the elderly population of Cache County, Utah (Arch.
Lending support to the relationship between late-life dementia and high blood pressure was a third population-based study, this one in more than 5,000 individuals aged 65 years and older from Cache County, Utah (the Cache County Study