We found that three genes had nominally significant interactions (p <0.05; Excel Table S9): cysteine-rich angiogenic inducer 61 (CYR61
; also known as cellular communication network factor 1; CCN1), cyclin-dependent kinase inhibitor 1C (CDKN1C), and COPG2.
miRNA: micro-RNA RISC: RNA-induced silencing complex Ago2: Argonaut 2 TRBP: Human immunodeficiency virus transactivating response RNA-binding protein IL: Interleukins RANKL: Receptor activator of nuclear factor kappa-B ligand TLR: Toll-like receptors TNF-[alpha]: Tumor necrosis factor alpha MMP: Matrix metalloproteinases CCL2: Chemokine ligand 2 CDK2: Cyclin-dependent kinase 2 Cyr61
: Cysteine-rich angiogenic inducer 61 TNFAIP3: Tumor necrosis factor alpha-induced protein 3 BCL2: B cell lymphoma 2 M-CSF: Macrophage colony-stimulating factor IKK-[alpha]: Inhibitor of nuclear factor kappa-B kinase subunit alpha PADI4: Peptidylarginine deiminase 4 gene Tregs: Regulatory T cells PTPN22: Protein tyrosine phosphatase, nonreceptor type 22 gene.
The expressions of YAP-targeted genes, Areg, Birc5, Ctgf, and Foxm1, were increased after PHx, and infusion of MSCs further significantly increased the expressions of these genes, but there was no effect on the expression of Cyr61
Huo et al., "Cyr61
induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis," Journal of Immunology, vol.
Of these, the upregulated genes were found to be HSPs, BAG3, SOCS3, GADD45G, GCLM, VLDLR, CYR61
, DUSP1, DUSP5, FOS, EGR1, MAFB, NR4A1, PROP1, TGFB1, DNAJB1, ADM, and DDIT3.
Kimura et al., "CCN1 (Cyr61
) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS-4 (aggrecanase 1) activity," Arthritis & Rhematology, vol.
Modulation of the isoform expression of Cyr61
and Integrin-ov in human microvascular endothelial cells.
The CCN family of matricellular proteins is a complex family containing CCN1 to CCN6, namely, CCN1 (cysteinerich protein 61, Cyr61
), CCN2 (connective tissue growth factor, CTGF), CCN3 (nephroblastoma overexpressed gene, NOV), CCN4 (WNT1 inducible signaling pathway protein-1, WISP1), CCN5 (WISP2), and CCN6 (WISP3).
It is a 38 kD cysteine-rich peptide that belongs to the emerging CCN (CYR61
, CTGF, NOV) family of multifunctional growth factors .
, a Product of a Growth Factor-Inducible Immediate-Early Gene, Promotes Cell Proliferation, Migration, and Adhesion Molecular and Cellular Biology.
MicroRNA-155 contributes to preeclampsia by down-regulating CYR61
. Am J Obstet Gynecol, 202(5), 466 e461-467.