Some studies demonstrated reductions in drug levels of up to 50% with strong CYP3A4
and P-glycoprotein inducers.
Although the role of CYP3A4
and CYP3A5 enzyme at the tacrolimus metabolism is reported, the fraction of CYP 3A5 involvement remains unclear.
Boceprevir, telaprevir, and simeprevir inhibit CYP3A4
to varying degrees and therefore could affect psychotropic medications metabolized by this enzyme.
is one of the most abundantly expressed cytochromes in human liver contributing on average up to 30% to the microsomal pool of P450 system.
, and CYP2C19, which are other isomers of cytochrome P450, selectively perform hydroxylation of R-warfarin and converts it into inactive metabolites.
As stated earlier, the concomitant use of flibanserin with alcohol or a moderate or strong CYP3A4
inhibitor Can result in severe hypotension and syncope.
The risks of hypotension and syncope, and central nervous system depression also are exacerbated by moderate or strong CYP3A4
Pooled human liver microsomes and specific human CYP3A4
isoform were obtained from Corning Gentest Corporation (Woburn, MA, USA) and stored at -150[degrees]C until use.
Of less relevance in fibroids, but important for women's health, a fraction of E1 and E2 can also undergo phase 1 detoxification processes via CYP1B1, CYP1A1 and CYP3A4
, resulting in 4-hydroxyestrone (4OHE1) and 4-hydroxyestradiol (4OHE2) which have been identified as having potent oestrogenic3 and tumorigenic activity due to their ability to interact with DNA.
Recently, a newly discovered polymorphism in CYP3A4
and CYP3A5 are both expressed in liver and intestine, but CYP3A5 is the predominant form expressed in extrahepatic tissues  and may account for up to 50% of the total CYP3A activity in liver .
Oral alprazolam is extensively metabolized by the human hepatic CYP3A4
to form two less active metabolites, alphahydroxy alprazolam and 4-hydroxyalprazolam.