The coadministration of Vaprisol with potent
CYP3A inhibitors, such as ketoconazole, itraconazole, clarithromycin, ritonavir, and indinavir, is contraindicated.
Enzymes/transporters: Drugs that induce P-gp or induce both
CYP3A and UGT1A1 can substantially decrease the concentration of components of Biktarvy.
Dose-dependent bioavailability and
CYP3A inhibition contribute to non-linear pharmacokinetics of voriconazole.
The prescribing information includes warnings of elevated transaminases and the risk for cataracts in children taking Symdeko and warns against taking Symdeko simultaneously with
CYP3A inducers.
Co-administration of strong
CYP3A inducers with NINLARO is not recommended.
Ranolazine Extended-Release Tablets are contraindicated in patients taking strong inhibitors of
CYP3A; patients taking inducers of
CYP3A; and patients with liver cirrhosis.
(25) demonstrated that long-term use of St John's wort activates selective induction of
CYP3A in the intestinal wall, but does not alter the function of CYP2C9, CYP1A2, or CYP2D6.
The analyst says the claims of this patent appear broad, including treatment of Cushing's and hormone-sensitive cancers by concomitant administration of Korlym and
CYP3A inhibitors such as ketoconazole and others.
Exclusion criteria were as follows: (1) a history of psychiatric disease, significant cardiovascular disease, hepatic or renal dysfunction, or diabetes mellitus; (2) alcohol or drug abuse or chronic analgesic use; (3) opioid intolerance; (4) pregnant or lactating women; or (5) consuming drugs or foods known to inhibit or induce the expression of
CYP3A enzymes in 2 weeks before surgery.{Table 1}
(3) The
CYP3A subfamily is the most abundant CYP enzyme and represents about 30% of the total CYP in the human liver.
