CYP3A4

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CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
References in periodicals archive ?
The human CYP3A subfamily consists of four Known members - CYP3A4, 3A5, 3A7 and 3A43 (Lamba et al.
The subtypes of CYP enzymes tested for were: ethoxyresorufin O-de-ethylase, CYPIA1; methoxyresorufin O-demethylase, CYPIA2; pentoxyresorufin O-dealkylase, CYP2B; (S)-warfarin 7-hydroxyIase, CYP2C; p-nitrophenol hydroxylase, CYP2E1; and testosterone 6[beta]-hydroxylase, CYP3A.
The CYP3A subfamily in humans comprises the 3A3, 3A4, and 3A5 isoenzymes in adults and the 3A7 isoenzyme in fetal liver.
Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug-drug interaction model rats.
This study investigated the effect of Danshen on the pharmacodynamic-pharmacokinetic (PD-PK) effects of midazolam, a model CYP3A probe substrate.
The relative abundance and significance of individual CYP enzyme in human drug metabolism varies, the more important CYP isoform families include CYP1A, CYP2C, CYP2D and CYP3A.
Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression.
CYP3A variation and the evolution of salt-sensitivity variants.
CYP3A members are the most abundant CYPs in rat and human liver and small intestine (4, 5).
Wang D, Sadee W (2012) The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy.