CYP3A4

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CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
References in periodicals archive ?
The coadministration of Vaprisol with potent CYP3A inhibitors, such as ketoconazole, itraconazole, clarithromycin, ritonavir, and indinavir, is contraindicated.
Enzymes/transporters: Drugs that induce P-gp or induce both CYP3A and UGT1A1 can substantially decrease the concentration of components of Biktarvy.
Dose-dependent bioavailability and CYP3A inhibition contribute to non-linear pharmacokinetics of voriconazole.
The prescribing information includes warnings of elevated transaminases and the risk for cataracts in children taking Symdeko and warns against taking Symdeko simultaneously with CYP3A inducers.
Ranolazine Extended-Release Tablets are contraindicated in patients taking strong inhibitors of CYP3A; patients taking inducers of CYP3A; and patients with liver cirrhosis.
(25) demonstrated that long-term use of St John's wort activates selective induction of CYP3A in the intestinal wall, but does not alter the function of CYP2C9, CYP1A2, or CYP2D6.
The analyst says the claims of this patent appear broad, including treatment of Cushing's and hormone-sensitive cancers by concomitant administration of Korlym and CYP3A inhibitors such as ketoconazole and others.
Exclusion criteria were as follows: (1) a history of psychiatric disease, significant cardiovascular disease, hepatic or renal dysfunction, or diabetes mellitus; (2) alcohol or drug abuse or chronic analgesic use; (3) opioid intolerance; (4) pregnant or lactating women; or (5) consuming drugs or foods known to inhibit or induce the expression of CYP3A enzymes in 2 weeks before surgery.{Table 1}