PPIF

(redirected from CYP3)

PPIF

A gene on chromosome 10q22-q23 that encodes peptidylprolyl cis-trans isomerase F (cyclophilin F), which, as with other PPIs, accelerates protein folding. It catalyses the cis-trans isomerisation of proline-imidic peptide bonds in oligopeptides.
References in periodicals archive ?
On the other hand, apixaban and phenytoin share the hepatic enzyme CYP3 A4, and their concurrent use will lower its effectiveness (Lehne, 2013).
Coadministering a cytochrome P450 isoenzyme 3A4 (CYP3A4)inhibiting macrolide antibiotic, such as clarithromycin or erythromycin) (but not azithromycin) with atorvastatin (Lipitor[R]), simvastatin (Zocor[R]), or lovastatin (Mevacor[R]), which are metabolized by CYP3 A4, is associated with a fourfold to 10-fold increase in statin concentrations.
In addition to P-gp, Caco-2 cells express the metabolizing enzyme CYP3A and nuclear receptors such as pregnane X receptor (PXR), which regulate the expression of ABCB1 and CYP3.
Deltagen's XenoPharm Technology features both cell-based and in vivo screens for the major xenobiotic receptors SXR (steroid X receptor; also known as hPXR, or human pregnane X receptor) and CAR, as well as the cytochrome P- 450 enzyme CYP3.
Three CYP gene families, designated CYP1, CYP2, and CYP3, encode the cytochrome P450 enzymes that play the major role in human xenobiotic metabolism (Table 2) [7,10,35].
The human CYP forms that metabolize xenobiotics belong to the families CYP1, CYP2 and CYP3.