PPIF

(redirected from CYP3)

PPIF

A gene on chromosome 10q22-q23 that encodes peptidylprolyl cis-trans isomerase F (cyclophilin F), which, as with other PPIs, accelerates protein folding. It catalyses the cis-trans isomerisation of proline-imidic peptide bonds in oligopeptides.
References in periodicals archive ?
24] In humans, the CYP1, CYP2, and CYP3 families are involved in hepatic drug metabolism.
Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP) 1, CYP2 and CYP3 families in 22 different human tissues.
On the other hand, apixaban and phenytoin share the hepatic enzyme CYP3 A4, and their concurrent use will lower its effectiveness (Lehne, 2013).
In addition to P-gp, Caco-2 cells express the metabolizing enzyme CYP3A and nuclear receptors such as pregnane X receptor (PXR), which regulate the expression of ABCB1 and CYP3.
Over 70 CYP gene families have been described so far and are further divided into families and subfamilies of which CYP1, CPY2 and CYP3, are involved in hepatic drug metabolism.
Coadministering a cytochrome P450 isoenzyme 3A4 (CYP3A4)inhibiting macrolide antibiotic, such as clarithromycin or erythromycin) (but not azithromycin) with atorvastatin (Lipitor[R]), simvastatin (Zocor[R]), or lovastatin (Mevacor[R]), which are metabolized by CYP3 A4, is associated with a fourfold to 10-fold increase in statin concentrations.
Las familias CYP1, CYP2 y CYP3 contienen las enzimas principalmente involucradas en el metabolismo de compuestos endogenos como las drogas.
En humanos se han descrito al menos 18 familias y 44 subfamilias CYP metabolizadoras de xenobioticos, de las cuales solo las familias CYP1, CYP2 y CYP3 tienen importancia en el metabolismo de farmacos (Cuadro 4) (7,16).
Three CYP gene families, designated CYP1, CYP2, and CYP3, encode the cytochrome P450 enzymes that play the major role in human xenobiotic metabolism (Table 2) [7,10,35].
The human CYP forms that metabolize xenobiotics belong to the families CYP1, CYP2 and CYP3.