PPIF

(redirected from CYP3)

PPIF

A gene on chromosome 10q22-q23 that encodes peptidylprolyl cis-trans isomerase F (cyclophilin F), which, as with other PPIs, accelerates protein folding. It catalyses the cis-trans isomerisation of proline-imidic peptide bonds in oligopeptides.
References in periodicals archive ?
24] In humans, the CYP1, CYP2, and CYP3 families are involved in hepatic drug metabolism.
Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP) 1, CYP2 and CYP3 families in 22 different human tissues.
Hepatic Cyp1a2 Expression Reduction during Inflammation Elicited in a Rat Model of Intermittent Hypoxia
On the other hand, apixaban and phenytoin share the hepatic enzyme CYP3 A4, and their concurrent use will lower its effectiveness (Lehne, 2013).
Oral anticoagulants: the move beyond warfarin
In addition to P-gp, Caco-2 cells express the metabolizing enzyme CYP3A and nuclear receptors such as pregnane X receptor (PXR), which regulate the expression of ABCB1 and CYP3.
Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells
Over 70 CYP gene families have been described so far and are further divided into families and subfamilies of which CYP1, CPY2 and CYP3, are involved in hepatic drug metabolism.
Over-the-counter and purchase-on-internet medications--implications for psychiatry
Coadministering a cytochrome P450 isoenzyme 3A4 (CYP3A4)inhibiting macrolide antibiotic, such as clarithromycin or erythromycin) (but not azithromycin) with atorvastatin (Lipitor[R]), simvastatin (Zocor[R]), or lovastatin (Mevacor[R]), which are metabolized by CYP3 A4, is associated with a fourfold to 10-fold increase in statin concentrations.
Taking a macrolide with a statin raises risk of statin toxicity
Las familias CYP1, CYP2 y CYP3 contienen las enzimas principalmente involucradas en el metabolismo de compuestos endogenos como las drogas.
Citocromo P450 2A6 (CYP2A6) humano y su relacion con el consumo de tabaco
CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7.
Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine
En humanos se han descrito al menos 18 familias y 44 subfamilias CYP metabolizadoras de xenobioticos, de las cuales solo las familias CYP1, CYP2 y CYP3 tienen importancia en el metabolismo de farmacos (Cuadro 4) (7,16).
La farmacogenomica en medicina
Three CYP gene families, designated CYP1, CYP2, and CYP3, encode the cytochrome P450 enzymes that play the major role in human xenobiotic metabolism (Table 2) [7,10,35].
Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function
The human CYP forms that metabolize xenobiotics belong to the families CYP1, CYP2 and CYP3.
Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids
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