CYP27A1

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CYP27A1

A gene on chromosome 2q33-qter that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP27A1 is a mitochondrial protein that oxidises cholesterol intermediates as part of the bile-synthesis pathway. It catalyses the first step in the oxidation of the side chain of sterol intermediates and has a vitamin D3-25-hydroxylase activity. Because the conversion of cholesterol to bile acids is the major route for eliminating cholesterol from the body, CYP27A1 is important for cholesterol homeostasis.

Molecular pathology
CYP27A1 mutations cause cerebrotendinous xanthomatosis.
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Quantitative RT-PCR analyses revealed that EPA and/or DHA significantly downregulate the expression of genes controlling BA synthesis (CYP7A1 and CYP27) and uptake (NTCP), while genes involved in efflux (such as MRP2, MRP3, MRP4, and OST[beta]) and metabolism (SULT2A1) were upregulated (Figure 1(a)).
Finally, analyses of cotreatment also evidenced the gene-specific nature of the response to n-3 PUFAs; that is, genes such as MRP2 (Figure 1(d)) were additively activated by EPA and DHA, while, for FGFR4 (Figure 1(d)), CYP7A1, or CYP27 (SF3), the presence of the 2 n-3 PUFAs did not lead to improved regulatory events, when compared to each omega-3 alone.
As illustrated on SF4, with the exception of CYP27 mRNA levels that were significantly reduced only in BSA-free treated cells, no other significant differences were detected between the 2 formulations.
Skin is an autonomous organ in synthesis, two-step activation and degradation of vitamin D(3): CYP27 in epidermis completes the set of essential vitamin D(3)-hydroxylases.
(8.) Schuessler M, Astecker N, Herzig G, Vorisec G, Schuster I: Skin is an autonomous (3): CYP27 in epidermis completes the set of essential vitamin D (3)-hydroxylases.