En humanos se han descrito al menos 18 familias y 44 subfamilias CYP metabolizadoras de xenobioticos, de las cuales solo las familias CYP1, CYP2
y CYP3 tienen importancia en el metabolismo de farmacos (Cuadro 4) (7,16).
Organization, structure and evolution of the CYP2
gene cluster on human chromosome 19.
Wang and Hoffman's group combined work at the computer and at the bench to accurately assemble the mouse Cyp2 cluster, located on chromosome 7, and to compare it with the CYP2 cluster on human chromosome 19.
Coupled with the group's similar work with the related human CYP2 gene cluster, the mouse mapping data show how although not why the two species have expanded their CYP2 genes in the time since evolution separated them.
According to the charge sheet, between May and July 2007 the defendants conspired to defraud by securing illegal loans worth CYP2
.1m (e1/43.6m) from the Strovolos co-op.
family contains six enzymes with clinically relevant polymorphisms.
Glycyrrhiza uralensis and its main component glycyrrhizin had influence on the mRNA expression of CYP1 and CYP2
isozymes and may change the activity of CYPA3 [31-34].
The cytochrome P450 monooxygenase family (CYP1, CYP2
, and CYP3) are responsible for phase I metabolism and promote oxidation, hydroxylation, reduction, and hydrolysis.
gene family is large, having numerous subfamilies that are physically clustered together in the genome.
A cluster of Cyp2
genes on mouse chromosome 7 was mapped and analyzed in detail and compared with the homologous cluster on human chromosome 19.
Three CYP gene families, designated CYP1, CYP2
, and CYP3, encode the cytochrome P450 enzymes that play the major role in human xenobiotic metabolism (Table 2) [7,10,35].
According to the details, between May and July 2007, the defendants had conspired to defraud -- to secure illegal loans worth CYP2
.1m (e1/43.6m) from Strovolos co-op.