PPIG

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PPIG

A gene on chromosome 2q31.1 that encodes peptidylprolyl cis-trans isomerase G (cyclophilin G), which, as with other PPIs, accelerates protein folding. It catalyses the cis-trans isomerisation of proline-imidic peptide bonds in oligopeptides. It may play a role in folding, transport and assembly of proteins, as well as in regulating pre-mRNA splicing.
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En humanos se han descrito al menos 18 familias y 44 subfamilias CYP metabolizadoras de xenobioticos, de las cuales solo las familias CYP1, CYP2 y CYP3 tienen importancia en el metabolismo de farmacos (Cuadro 4) (7,16).
The CYP2B6 gene is located, together with a closely related pseudogene CYP2B7P1, in a CYP2 gene cluster on chromosome 19 (16).
Wang and Hoffman's group combined work at the computer and at the bench to accurately assemble the mouse Cyp2 cluster, located on chromosome 7, and to compare it with the CYP2 cluster on human chromosome 19.
Coupled with the group's similar work with the related human CYP2 gene cluster, the mouse mapping data show how although not why the two species have expanded their CYP2 genes in the time since evolution separated them.
The cytochrome P450 monooxygenase family (CYP1, CYP2, and CYP3) are responsible for phase I metabolism and promote oxidation, hydroxylation, reduction, and hydrolysis.
The CYP2 gene family is large, having numerous subfamilies that are physically clustered together in the genome.
The mouse cluster includes 22 loci from the same six CYP2 subfamilies--Cyp2a, Cyp2b, Cyp2f, Cyp2g, Cyp2s, Cyp2t--that are found in the human cluster.
Detailed physical mapping using genomic clones proved to be an extremely fruitful approach for understanding one human gene cluster, the CYP2 cluster on chromosome 19 (Hoffman et al.
Three CYP gene families, designated CYP1, CYP2, and CYP3, encode the cytochrome P450 enzymes that play the major role in human xenobiotic metabolism (Table 2) [7,10,35].