CYP17A1


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CYP17A1

A gene on chromosome 10q24.3 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP17A1 localises to the endoplasmic reticulum and has 17 alpha-hydroxylase and 17, 20-lyase activities; it is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens and oestrogens.

Molecular pathology
CYP17A1 mutations are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism and adrenal hyperplasia.
References in periodicals archive ?
39] In the first pathway, it converts into the DHEA by CYP17A1 and subsequently by HSD3B1, DHEA converts into androstenedione.
Steroidogenesis is modulated through the regulation of the genes involved in the hypothalamic-pituitary--steroidogenetic axis, such as: STAR, CYP11A1, CYP17A1, CYP19A1, LH and INHA(30).
Antitumour activity of docetaxel following treatment with the CYP17A1 inhibitor abiraterone: Clinical evidence for cross-resistance?
The once-daily oral medication AA (marketed as Zytiga, Abiratas, Abretone and Abirapro) is "a potent inhibitor of steroid hormone anabolism," according to the research team, and the drug is already known to interfere with the CYP17A1 enzymes required in the body's production of androgens.
Regarding the group with a defined diagnosis, androgen receptor defects (n = 25), 5[alpha]-reductase type 2 deficiency (n = 20), and hypogonadotropic hypogonadism (n = 12), including six with associated hypopituitarism, were found with higher frequencies, followed by the group of defects in testosterone synthesis that included one patient with HSD3B2 deficiency, one with CYP17A1 deficiency, and two with HSD17B3 deficiency.
1, 3) This enzyme is encoded by the CYP17A1 gene and has been mapped to chromosome 10q24-25 in the adrenal cortex (zona reticularis) and gonads.
Pioglitazone(Pio) Rosiglitazone(Posi) Gene Fold Fold Symbol Change p-value Change p-value CYP17A1 CYP1A1 17.