CYP17A1

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CYP17A1

A gene on chromosome 10q24.3 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP17A1 localises to the endoplasmic reticulum and has 17 alpha-hydroxylase and 17, 20-lyase activities; it is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens and oestrogens.

Molecular pathology
CYP17A1 mutations are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism and adrenal hyperplasia.
References in periodicals archive ?
The '438 patent describes administration of a therapeutically effective amount of a CYP17 inhibitor, such as abiraterone acetate, with a therapeutically effective amount of at least one additional therapeutic agent including, but not limited to, an anti-cancer agent, such as mitoxantrone, paclitaxel, docetaxel, leuprolide, goserelin, triptorelin, seocalcitol, bicalutamide, or flutamide, or a steroid, such as hydrocortisone, prednisone, or dexamethasone, the ruling states.
CYP11a, cytochrome P450 11a (cholesterol sidechange cleavage protein); CYP17, cytochrome P450 17 (e.
Novel mutation of the CYP17 gene in two unrelated patients with combined 17alpha-hydroxylase/17,20-lyase deficiency: demonstration of absent enzyme activity by expressing the mutant CYP17 gene and by three-dimensional modeling.
Secondly, to investigate their effects on the expression of developmental genes including PCNA, BMPR-IB, BMPR-II, FSH-R, CYP17 and ZP3 by real-time RT-PCR.
In vivo treatment with GDF-9 stimulates primordial and primary follicle progression and theca cell marker CYP17 in ovaries of immature rats.
005) and increased expression of canonical androgen receptor (AR) signaling components AR-N, ARC19, CYP17 (p<0.
19,20) An Interesting study published in Environmental Health linked SNPs of CYP1A1, CYP17, and COMT and levels of serum perfluorooctane sulfonate (PFOS) and periluorooctanolc acid (PFOA) to Increased risk of breast cancer.
Insulin-sensitizers have a positive effect in PCOS patients through normalization of hyperinsulinaemia that otherwise amplifies the excessive androgen production from the ovary theca cells via CYP17 phosphorylation and lower levels of SHBG.
Theca cells from PCOS ovaries which have been correlated to increased expression and/or activity of CYP17 synthesize increased levels of androgens compared with normal theca cells.
in 1980, (68) and CYP17 from guinea pig adrenal cortex microsomes by Kominami et al.
Abiraterone acetate is the prodrug of abiraterone that works by inhibiting the CYP17 enzyme complex in the androgen biosynthesis pathway which is important in the production of testosterone and other androgens.