CYP 2E1

CYP 2E1

microsomal enzyme that participates in the oxidation of ethanol and acetaminophen. Inhibited by disulfiram and induced by ethanol and isoniazid (INH). Believed to be responsible for the hepatotoxic metabolite of acetaminophen.

CYP 2E1

Abbreviation for a microsomal enzyme that participates in the oxidation of ethanol and acetaminophen. Inhibited by disulfiram and induced by ethanol and isoniazid (INH). Believed to be responsible for the hepatotoxic metabolite of acetaminophen.
References in periodicals archive ?
[4,8,12,13] Six major classes of CYP isoenzymes that play a vital role in drug biotransformation are CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, CYP 2E1, and CYP 3A4.
The crude extract of this plant inhibits metabolic isoenzyme CYP 2E1 in mouse and human.
There are experimental data showing that dry extract from Silybum marianum significantly inhibited a number of CYPs including CYP 3A4 and CYP 2E1 (Doehmer et al.
Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride.
el CYP 2E1 y el CYP 1A1 estan presentes en la especie humana, rata, raton, hamster y otros mamiferos (Anzenbacher y Anzenbacherova, 2001; Shimada y Fujii-Kuriyama, 2004) y otros son caracteristicos de una especie en particular (p.e.
En la subfamila CYP 2E se encuentra una isoforma enzimatica con un papel importante en el metabolismo del etanol: el CYP 2E1. Este representa un 10% del CYP450 total en el tejido hepatico (Cozza y Amstrong, 2001).
The CYP 2E1 pathway has low initial catalytic efficiency compared with the ADH/ALDH pathway, but it may metabolize alcohol up to 10 times faster after chronic alcohol consumption or cigarette smoking and accounts for metabolic tolerance.
El metabolismo del etanol involucra la participacion de isoenzimas del citocromo [P.sub.450] (CYP), principalmente con la contribucion de la isoenzima 2E1 (CYP 2E1), cuya actividad es inducida por la exposicion cronica al alcohol.
(3) Numerosos estudios indican que el consumo cronico de etanol aumenta la actividad de diversas especies del CYP, en particular de la isoenzima CYP 2E1. (3, 4) Se sabe que en la oxidacion del etanol estan implicadas mas de una isoforma del CYP, siendo la contribucion de CYP2E1 la mas importante de esta reaccion.
Huh7 cells were transfected with NS5A-expressing constructs and subjected to quantification of CYP 2E1 levels by real-time RT-PCR (a) or Western blotting (b) 40 hrs after transfection.
Transcript Sequence NOX1 Sense 5'-TTAACAGCACGCTGATCCTG-3' Antisense 5'-CTGGAGAGAATGGAGGCAAG-3 NOX4 Sense 5'-GCTGACGTTGCATGTTTCAG-3' Antisense 5'-CGGGAGGGTGGGTATCTAA-3' COX-2 Sense 5'-CCATGTCAAAACCGAGGTGTAT-3' Antisense 5'-TCCGGTGTTGAGCAGTTTTCT-3' TGF[beta]1 Sense 5'-GCAGCACGTGGAGCTGTA-3' Antisense 5'-CAGCCGGTTGCTGAGGTA-3' CYP 2E1 Sense 5'-GACTGTGGCCGACCTGTT-3' Antisense 5'-ACTACGACTGTGCCCTTGG-3' Ero1[alpha] Sense 5'-GCATTGAAGAAGGTGAGCAA-3' Antisense 5'-ATCATGCTTGGTCCACTGAA-3' Ero1[beta] Sense 5'-GGGCCAAGTCATTAAAGGAA-3' Antisense 5'-TTTATCGCACCCAACACAGT-3' Table 4: Secretion of TGF[beta]1 from Huh7 cells transfected with pVax1 or plasmids expressing full-length NS5A or its domain 1.
Rabbit polyclonal antibody CYP 2E1 and HO-1 was provided by Santa Cruz (California.