The CYP 2D6
activity score: translating genotype information into a qualitative measure of phenotype.
In those individuals with the poor metabolizer phenotype for CYP 2D6
, codeine causes only nausea and vomiting and has no analgesic effects.
After statistical adjustment for age, socioeconomic status, comorbidity, use of other CYP 2D6 drugs, and timing and duration of tamoxifen therapy, investigators found that the breast cancer mortality risk was increased 24% among women who were coprescribed paroxetine during 25% of their tamoxifen treatment.
Kelly hypothesized that the explanation lies in the degree to which various SSRIs inhibit CYP 2D6.
I would like to see further data on that and would use caution in using any of the drugs that inhibit CYP 2D6 in women who are taking tamoxifen, said Dr.
These markers have been a reliable guide for treatment and predictor of breast cancer outcomes; however, several emerging biomarkers, such as the CYP 2D6 genotype to determine tamoxifen (Soltamox([TM]), AstraZeneca Pharmaceuticals, LP) efficacy, are also being researched extensively.
The efficacy of tamoxifen therapy for the treatment of breast cancer varies widely among individuals, which has led to several trials trying to determine whether there is an association between the CYP 2D6 genotype and the effectiveness of tamoxifen in preventing breast cancer recurrence," said Dr.
Carlson stressed that the NCCN Guidelines Panel feels that the available studies examining CYP 2D6 are inconsistent, therefore the Panel does not recommend routine testing for CYP 2D6 genotype.
In poor CYP 2D6
metabolizers, the effect of pesticides was increased twofold.