CYP 1A2

CYP 1A2

microsomal enzyme, the substrates of which include theophylline, antidepressants, and tacrine. It is inhibited by grapefruit juice and quinolones, and induced by smoking, phenobarbital, phenytoin, rifampin, and omeprazole.

CYP 1A2

A microsomal enzyme, the substrates of which include theophylline, antidepressants, and tacrine. It is inhibited by grapefruit juice and quinolones, and induced by smoking, phenobarbital, phenytoin, rifampin, and omeprazole.
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CYP 1A2 (IF/IF) and caffeine (HBP, Ml, CHD, tachycardia, stiff aorta, PWV, Al, SBP, PP, vascular inflammation, increased catecholamines)
Avoid caffeine in CYP 1A2 SNP (IF/IF and IF/IA alleles).
4,8,12,13] Six major classes of CYP isoenzymes that play a vital role in drug biotransformation are CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, CYP 2E1, and CYP 3A4.
18,19,25] An active constituent, gincolic acid, is found to inhibit CYP 1A2, 2C9, 2C19, and 3A4 isoenzymes.
9% Olanzapine levels increased because of loss of interaction between metoprolol, a CYP 2D6 substrate, and olanzapine 24% Rebound from abrupt discontinuation of the beta blocker is causing extrapyramidal symptoms and akathisia 42% Olanzapine levels increased after he stopped taking omeprazole, a potent CYP 1A2 inhibitor 25% Olanzapine levels increased because greater stomach acidity enhanced absorption following discontinuation of the proton pump inhibitor * Data obtained via CurrentPsychiatry.
Therefore, the aim of this study was to investigate the effects of MA on the CYP 1A2, 2C9/11, 2D1/6, 2E1 and 3A2/4 activities by human and rat liver microsomes and specific CYP isoforms.
14) CYP 1A2 is responsible for 10% to 15% of CYP activity.
Table 2 Effects of CYP/PGP induction on atypical antipsychotics Antipsychotic Metabolic pathways Effect of induction Aripiprazole 2D6 and 3A4 convert 3A4 induction decreases aripiprazole to active maximum concentration of metabolite aripiprazole and dehydro-aripiprazole metabolite by 70% Clozapine Multiple enzymes convert Loss of smoking-related clozapine to 1A2 induction results in N-desmethylclozapine; mean 50% increase in serum contributions of CYP 1A2, levels 2C19, 3A4, 2C9, and 2D6 are 30%, 24%, 22%, 12%, and 6%, respectively, with CYP 1A2 predominantly involved at low concentrations Olanzapine Direct glucuronidation or Carbamazepine use 1A2-mediated oxidation to increases clearance by N-desmethlyolanzapine 50%.
memorizing the list of CYP 1A2 and CYP 3A4/PGP inducers.