CYP 1A2

CYP 1A2

microsomal enzyme, the substrates of which include theophylline, antidepressants, and tacrine. It is inhibited by grapefruit juice and quinolones, and induced by smoking, phenobarbital, phenytoin, rifampin, and omeprazole.

CYP 1A2

A microsomal enzyme, the substrates of which include theophylline, antidepressants, and tacrine. It is inhibited by grapefruit juice and quinolones, and induced by smoking, phenobarbital, phenytoin, rifampin, and omeprazole.
References in periodicals archive ?
Tenders are invited for Inhibition of human cyp isoforms (ic50 determination against cyp 1a2,2a6,2b6,2d6,2e1 and 3a4
[13] (~52kD) Obermayer-Straub IB human CYPs CYP 1A2 Adult and [14] pediatric Human liver Aguilera et al.
The inhibition of CYP 1A2, 2C9, 2C19, 2D6 and 3A4 isozymes by LDT5 was evaluated in human liver microsomes (pooled, from XenoTech, LLC) by monitoring the production of selective metabolites following incubation with probe substrates.
CYP 1A2 (IF/IF) and caffeine (HBP, Ml, CHD, tachycardia, stiff aorta, PWV, Al, SBP, PP, vascular inflammation, increased catecholamines)
[4,8,12,13] Six major classes of CYP isoenzymes that play a vital role in drug biotransformation are CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, CYP 2E1, and CYP 3A4.
ENLE significantly modulated the expression of bax, cyclin D1, and cytochrome P450 monooxygenases (CYP 1A1 and CYP 1A2) in a time-dependent manner in these cells.
Fluoxetine, fluvoxamine, and paroxetine are the SSRIs with the greatest likelihood of having a significant CYP 450 interaction by inhibiting the metabolism of medications mediated by CYP 2D6, CYP 1A2, and CYP 2C19.
9% Olanzapine levels increased because of loss of interaction between metoprolol, a CYP 2D6 substrate, and olanzapine 24% Rebound from abrupt discontinuation of the beta blocker is causing extrapyramidal symptoms and akathisia 42% Olanzapine levels increased after he stopped taking omeprazole, a potent CYP 1A2 inhibitor 25% Olanzapine levels increased because greater stomach acidity enhanced absorption following discontinuation of the proton pump inhibitor * Data obtained via CurrentPsychiatry.com, January 2009 SUGGESTED READING: Meyer JM, Leckband SG.
Proinflammatory cytokines, for instance, are known to downregulate albumin synthesis [27], to cause a dysfunction of mitochondria [26], and to diminish function of some P450 cytochromes like CYP 1A2, CYP 2E1, and CYP 7A1 [28,29].
Therefore, the aim of this study was to investigate the effects of MA on the CYP 1A2, 2C9/11, 2D1/6, 2E1 and 3A2/4 activities by human and rat liver microsomes and specific CYP isoforms.