CYP 1A2 (IF/IF) and caffeine (HBP, Ml, CHD, tachycardia, stiff aorta, PWV, Al, SBP, PP, vascular inflammation, increased catecholamines)
Avoid caffeine in CYP 1A2 SNP (IF/IF and IF/IA alleles).
4,8,12,13] Six major classes of CYP isoenzymes that play a vital role in drug biotransformation are CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, CYP 2E1, and CYP 3A4.
18,19,25] An active constituent, gincolic acid, is found to inhibit CYP 1A2, 2C9, 2C19, and 3A4 isoenzymes.
9% Olanzapine levels increased because of loss of interaction between metoprolol, a CYP 2D6 substrate, and olanzapine 24% Rebound from abrupt discontinuation of the beta blocker is causing extrapyramidal symptoms and akathisia 42% Olanzapine levels increased after he stopped taking omeprazole, a potent CYP 1A2
inhibitor 25% Olanzapine levels increased because greater stomach acidity enhanced absorption following discontinuation of the proton pump inhibitor * Data obtained via CurrentPsychiatry.
Therefore, the aim of this study was to investigate the effects of MA on the CYP 1A2
, 2C9/11, 2D1/6, 2E1 and 3A2/4 activities by human and rat liver microsomes and specific CYP isoforms.
14) CYP 1A2 is responsible for 10% to 15% of CYP activity.
Table 2 Effects of CYP/PGP induction on atypical antipsychotics Antipsychotic Metabolic pathways Effect of induction Aripiprazole 2D6 and 3A4 convert 3A4 induction decreases aripiprazole to active maximum concentration of metabolite aripiprazole and dehydro-aripiprazole metabolite by 70% Clozapine Multiple enzymes convert Loss of smoking-related clozapine to 1A2 induction results in N-desmethylclozapine; mean 50% increase in serum contributions of CYP 1A2, levels 2C19, 3A4, 2C9, and 2D6 are 30%, 24%, 22%, 12%, and 6%, respectively, with CYP 1A2 predominantly involved at low concentrations Olanzapine Direct glucuronidation or Carbamazepine use 1A2-mediated oxidation to increases clearance by N-desmethlyolanzapine 50%.
memorizing the list of CYP 1A2 and CYP 3A4/PGP inducers.