(~52kD) Obermayer-Straub IB human CYPs CYP 1A2
Adult and  pediatric Human liver Aguilera et al.
Similarly, CYP 1A2
mRNA was also induced by about 10-fold by BNF (Figure 5(c)).
The inhibition of CYP 1A2
, 2C9, 2C19, 2D6 and 3A4 isozymes by LDT5 was evaluated in human liver microsomes (pooled, from XenoTech, LLC) by monitoring the production of selective metabolites following incubation with probe substrates.
(IF/IF) and caffeine (HBP, Ml, CHD, tachycardia, stiff aorta, PWV, Al, SBP, PP, vascular inflammation, increased catecholamines)
[4,8,12,13] Six major classes of CYP isoenzymes that play a vital role in drug biotransformation are CYP 1A2
, CYP 2C19, CYP 2C9, CYP 2D6, CYP 2E1, and CYP 3A4.
ENLE significantly modulated the expression of bax, cyclin D1, and cytochrome P450 monooxygenases (CYP 1A1 and CYP 1A2
) in a time-dependent manner in these cells.
Fluoxetine, fluvoxamine, and paroxetine are the SSRIs with the greatest likelihood of having a significant CYP 450 interaction by inhibiting the metabolism of medications mediated by CYP 2D6, CYP 1A2
, and CYP 2C19.
9% Olanzapine levels increased because of loss of interaction between metoprolol, a CYP 2D6 substrate, and olanzapine 24% Rebound from abrupt discontinuation of the beta blocker is causing extrapyramidal symptoms and akathisia 42% Olanzapine levels increased after he stopped taking omeprazole, a potent CYP 1A2
inhibitor 25% Olanzapine levels increased because greater stomach acidity enhanced absorption following discontinuation of the proton pump inhibitor * Data obtained via CurrentPsychiatry.com, January 2009 SUGGESTED READING: Meyer JM, Leckband SG.
Proinflammatory cytokines, for instance, are known to downregulate albumin synthesis , to cause a dysfunction of mitochondria , and to diminish function of some P450 cytochromes like CYP 1A2
, CYP 2E1, and CYP 7A1 [28,29].
Therefore, the aim of this study was to investigate the effects of MA on the CYP 1A2
, 2C9/11, 2D1/6, 2E1 and 3A2/4 activities by human and rat liver microsomes and specific CYP isoforms.
(14) CYP 1A2
is responsible for 10% to 15% of CYP activity.