CLYD

(redirected from CYLD1)

CLYD

A gene on chromosome 16q12.1 that encodes a cytoplasmic protein with deubiquitinating activity and plays a key role in regulating pathways leading to NF-kappa-B activation, which affects cell survival, proliferation and differentiation.

Molecular pathology
CLYD mutations are causatively linked to cylindromatosis, multiple familial trichoepithelioma and Brooke-Spiegler syndrome.
References in periodicals archive ?
The gene associated with familial cylindromatosis, CYLD1 (cylindromatosis 1), is located on 16q12-13, and is a tumor suppressor gene.
CYLD1 is a 956-amino acid protein that is widely expressed.