CYCS


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CYCS

A gene on chromosome 7p15.3 that encodes cytochrome c, an electron carrier protein, which transfers electrons from the heme group of the cytochrome c1 subunit of cytochrome reductase to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. CYCS plays a role in apoptosis by suppressing anti-apoptotic members or by activating pro-apoptotic members of the Bcl-2 family, leading to altered mitochondrial membrane permeability and the release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 activates caspase-9, which then accelerates apoptosis by activating other caspases.

Molecular pathology
Defects in CYCS cause thrombocytopaenia type 4.
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References in periodicals archive ?
Our study is the first one to specifically examine the acute effects of CycS and SS interventions on strength level (internal rotation strength, external rotation strength and scapular plane abduction strength) and spike skill level (spike speed, spike hit rate on target).
The results revealed that both SS and CycS protocol applied in this study were effective to increase shoulder flexibility.
The main finding of this study supported our hypothesis that 90 sec (2 set of 3x15 s) CycS intervention increased internal rotation strength.
According to this study's results, it can be declared that CycS has similar effects both on lower and upper limb.
CycS did not manifest the expected stretching effect on these muscles in terms of assessment process and repetition.
[35,36] Similarity this study and previous studies showed that CycS and SS did not affect volleyball players spike speed.
[6] reported that the musculo-articular complex response to CycS and SS may be different.
Our aim was to analyze the effects of acute CycS and SS on the rotator cuff muscle, so the leg muscles were not stretched.
In conclusion, both CycS and SS interventions were effective in improving shoulder flexibility.