Loos et al., "Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7
binding and signaling and reduces lymphocyte and endothelial cell migration," Blood, vol.
Hao et al., "CXCL12 / CXCR4 / CXCR7
chemokine axis and cancer progression," Cancer Metastasis Reviews, vol.
For example, SOX-4 overexpression is correlated with poor survival rate, (70) and overexpression of chemokine receptor C-X-C chemokine receptor type 7 (CXCR7
) may promote disease progression and predicts metastasis and prognosis.
In addition, IL-8 of the prostate cancer cells also upregulated EGFRERK signaling through elevating CXCR7
transcripts and protein levels .
Su et al., "Chemokine receptor CXCR7
regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells," Journal of Experimental & Clinical Cancer Research, pp.
Five down-regulated miRNAs (bta-miR-424-5P, bta-miR-19b, bta-miR-29b, btamiR-30b, and bta-miR-2285) having sites binding to the mRNA of 12 distinct genes calponin 1 (CNN1), atypical chemokine receptor 3 (CXCR7
), endothelin receptor type (BEDNRB), fibrinogen alpha chain (FGA), insulin like growth factor binding protein 3 (IGFBP3), regulator of G-protein signaling 2 (RGS2), periostin, osteoblast specific factor (POSTN), monoamine oxidase (AMAOA), collagen type IV alpha 6 (COL4A6), dehydrogenase/reductase (SDR family) member 3 (DHRS3), solute carrier family 22 (organic anion transporter), member 7 (SLC22A7).
Global Markets Direct's, 'Atypical Chemokine Receptor 3 (Chemokine Orphan Receptor 1 or G-Protein Coupled Receptor 159 or G-Protein Coupled Receptor RDC1 Homolog or GPR159 or CXCR7
) - Pipeline Review, H1 2016', provides in depth analysis on Atypical Chemokine Receptor 3 (Chemokine Orphan Receptor 1 or G-Protein Coupled Receptor 159 or G-Protein Coupled Receptor RDC1 Homolog or GPR159 or CXCR7
) targeted pipeline therapeutics.
Xi et al., "A novel mechanism by which SDF protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7
and AMPK/p38 MAPK-mediated interleukin-6 generation," Diabetes, vol.
Revesz et al., "Chemokine/ chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7
," Pediatric Blood and Cancer, vol.
NB cells highly express both SDF-1 receptors, that is, CXCR4 and CXCR7
SDF-1/CXCR4 is considered an important signaling pathway for migration and invasion of NB, while SDF-1/CXCR7 is only associated with cell migration .
In particular, the chemokine (C-X-C motif) ligand 12 (CXCL12) and its receptors, CXCR4 and CXCR7
, have been involved in cancer cell proliferation, migration, and invasion [11-13].