CXCR6

CXCR6

A gene on chromosome 3p21 that encodes a member of the G protein-coupled receptor family which is a receptor for chemokine CXCL16 and a coreceptor for strains of HIV-2 and m-tropic HIV-1.
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CXCR6 deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-a-dependent autophagy.
We found the DMPs were located in the promoter regions of 12 genes (60%), including hypomethylated DMPs on seven upregulated genes (CSTA, CTSG, CTSZ, ELANE, LTBR, NFE2, and ODF3B) and hypermethylated DMPs on the five downregulated genes (CXCR6, FYN, PAG1, PRF1, and RUNX3).
Li, "Human trophoblasts recruited T lymphocytes and monocytes into decidua by secretion of chemokine CXCL16 and interaction with CXCR6 in the first-trimester pregnancy," The Journal of Immunology, vol.
Herbeck et al., "Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS," Journal of Infectious Diseases, vol.
It suppresses lung cancer progression by targeting FOXM1 [3]; inhibits hepatocellular carcinoma cell growth by targeting CXCR6 [4]; decreases glycolytic metabolism, proliferation, and invasion of breast cancer by targeting FGFR1 and MMP1 [5]; and prevents the malignant progression of prostate cancer cells by targeting STAT6 [6].
During the process, [CD4.sup.+] T cells are activated by IL-1[beta] and IL-18 produced by antigen-presenting cells (dendritic cells and macrophages), which have copious amounts of inflammasomes; as a consequence, there is an increase in the expression levels of chemotaxis-related proteins (such as osteopontin, CCR2, and CXCR6) [80].
Other ARGs are involved in many cellular processes, such as DEFB1, which has been implicated in cystic fibrosis pathogenesis [14], HLA-A, which is expressed in nearly all cells [15], CCL, which has been implicated in immunoregulatory and inflammatory processes [16], CXCR6, which is a chemokine (C-X-C motif) receptor [17], LY6D, which is a member of the lymphocyte antigen 6 complex [18], and APOBEC3B, which is a cytidine deaminase.
Moreover, overexpression of VEGFR-3 and chemokine receptors, such as CXCR2 (receptor of IL-8) and CXCR6 (receptor of CXCL6), has been found in endothelial cells and dermal fibroblasts isolated from SSc patients [44, 50, 51].
This variable highly correlated (absolute value > 0.15) with PPIA (1.11), TLR8 (0.70), TSG101 (0.49), CUL5 (0.40), Slurp1 (0.32), TLR4 (0.26), HLA-B (0.25), CXCR6 (0.18), TLR9 (-0.17), IDH1 (-0.20), HLA-A (-0.22), IRF1 (-0.24), NCOR2 (-0.24), TRIM5a (-0.30), HLA-C (-0.33), CXCR1 (-0.40), MYH9 (-0.50), and ZNRD1 (-0.91).
[6] While most HIV-1 variants use CCR5 and CXCR4 as the main co-receptor in vivo, up to 12 other chemokine co-receptors (including CCR2b, CXCR6 and GPR1) for HIV infection have been identified in vitro.
The epithelial surface expresses all the receptors necessary for HIV infection including CD4, CCR5, CXCR4 [64, 65], and various other G protein-coupled coreceptors (GPCRs) known to mediate entry of HIV into cells (including CCR2b, CXCR6, and GPR1) [63, 66], indicating a vast area of the female genital tract that can potentially be infected.
Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.