deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-a-dependent autophagy.
We found the DMPs were located in the promoter regions of 12 genes (60%), including hypomethylated DMPs on seven upregulated genes (CSTA, CTSG, CTSZ, ELANE, LTBR, NFE2, and ODF3B) and hypermethylated DMPs on the five downregulated genes (CXCR6
, FYN, PAG1, PRF1, and RUNX3).
Li, "Human trophoblasts recruited T lymphocytes and monocytes into decidua by secretion of chemokine CXCL16 and interaction with CXCR6
in the first-trimester pregnancy," The Journal of Immunology, vol.
Herbeck et al., "Multiple-cohort genetic association study reveals CXCR6
as a new chemokine receptor involved in long-term nonprogression to AIDS," Journal of Infectious Diseases, vol.
It suppresses lung cancer progression by targeting FOXM1 ; inhibits hepatocellular carcinoma cell growth by targeting CXCR6
; decreases glycolytic metabolism, proliferation, and invasion of breast cancer by targeting FGFR1 and MMP1 ; and prevents the malignant progression of prostate cancer cells by targeting STAT6 .
During the process, [CD4.sup.+] T cells are activated by IL-1[beta] and IL-18 produced by antigen-presenting cells (dendritic cells and macrophages), which have copious amounts of inflammasomes; as a consequence, there is an increase in the expression levels of chemotaxis-related proteins (such as osteopontin, CCR2, and CXCR6
Other ARGs are involved in many cellular processes, such as DEFB1, which has been implicated in cystic fibrosis pathogenesis , HLA-A, which is expressed in nearly all cells , CCL, which has been implicated in immunoregulatory and inflammatory processes , CXCR6
, which is a chemokine (C-X-C motif) receptor , LY6D, which is a member of the lymphocyte antigen 6 complex , and APOBEC3B, which is a cytidine deaminase.
Moreover, overexpression of VEGFR-3 and chemokine receptors, such as CXCR2 (receptor of IL-8) and CXCR6
(receptor of CXCL6), has been found in endothelial cells and dermal fibroblasts isolated from SSc patients [44, 50, 51].
This variable highly correlated (absolute value > 0.15) with PPIA (1.11), TLR8 (0.70), TSG101 (0.49), CUL5 (0.40), Slurp1 (0.32), TLR4 (0.26), HLA-B (0.25), CXCR6
(0.18), TLR9 (-0.17), IDH1 (-0.20), HLA-A (-0.22), IRF1 (-0.24), NCOR2 (-0.24), TRIM5a (-0.30), HLA-C (-0.33), CXCR1 (-0.40), MYH9 (-0.50), and ZNRD1 (-0.91).
 While most HIV-1 variants use CCR5 and CXCR4 as the main co-receptor in vivo, up to 12 other chemokine co-receptors (including CCR2b, CXCR6
and GPR1) for HIV infection have been identified in vitro.
The epithelial surface expresses all the receptors necessary for HIV infection including CD4, CCR5, CXCR4 [64, 65], and various other G protein-coupled coreceptors (GPCRs) known to mediate entry of HIV into cells (including CCR2b, CXCR6
, and GPR1) [63, 66], indicating a vast area of the female genital tract that can potentially be infected.
Genetic influence of CXCR6
chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.