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6] While most HIV-1 variants use CCR5 and CXCR4 as the main co-receptor in vivo, up to 12 other chemokine co-receptors (including CCR2b, CXCR6 and GPR1) for HIV infection have been identified in vitro.
HIV-1 and HIV-2 strains have been reported to be capable of utilising several alternative chemokine receptors, including CCR2b, CXCR4, CXCR6 and GPR1, to mediate infection of cells.
Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.
Additional genes of importance include CXCR6, prospero homeobox 1 (PROX1), an intergenic SNP between ribosomal protein S6 kinase alpha-6 (RPS6KA6) and cylicin-1 (CYLC1) genes (X chromosome).
CXCR6 is expressed in human prostate cancer in vivo and is involved in the in vitro invasion of PC3 and LNCap cells.