CXCR5


Also found in: Wikipedia.

CXCR5

A gene on chromosome 11q23.3 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds to B-lymphocyte chemoattractant (BLC) and is involved in B-cell migration into B-cell follicles of lymph nodes, spleen and Peyer patches.
References in periodicals archive ?
2,17) In the peripheral lymph nodes, LFA-1 on T cells is activated when HEV-associated chemokines including CCL21/ CCL19 and CXCL12 interact with their specific receptors on T cells, CCR7 and CXCR4, respectively, whereas LFA-1 on B cells is activated by interactions with CXCL13 via CXCR5.
Esta proliferacion de adipocitos y fibroblastos estromales, contienen en su membrana grandes cantidades de CXCL13, esto atrae mas leucocitos, como linfocitos B y macrofagos, estos ultimos reconocen tridimensionalmente a esta quimiocina a traves de la molecula CXCR5, con esto, empiezan a poblar el tejido adiposo visceral, macrofagos y otras celulas mieloides, que participaran tanto en procesos inmunologicos como en metabolicos.
Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine.
Se ha descrito una poblacion de iNKT foliculares que expresan PD1 y CXCR5 y pueden inducir la produccion de IL-21 en un linfoma de celulas B.
Estos linfocitos B autorreactivos tienen una menor capacidad de migrar hacia los nodulos linfaticos, probablemente porque expresan niveles bajos de CXCR5, lo que induce exclusion folicular y al no recibir senales de sobrevivencia mueren por apoptosis (14).
Expression of chemokine receptor, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma.
39) Furthermore, neddylation causes membrane targeting of the chemokine receptor CXCR5.
To date, most chemokine receptors, such as CXCR4 and CXCR5 on T cells and B cells, have been shown to be induced by Gi in the classic pathway, while CCR7 and CXCR4 have been shown to be dependent on Gq pathways only on dendritic cells (DCs) [38].