CXCR4 coreceptor | definition of CXCR4 coreceptor by Medical dictionary
A cell surface receptor found on T cells that facilitates entry of HIV-1into these cells. Synonym: fusin
References in periodicals archive
Scientists have genetically engineered mice not to express the CXCR4 coreceptor
On the other hand, viruses able to use CXCR4 coreceptors
(X4-tropic) tend to emerge later in the course of HIV infection, in comparison with R5 strains, and are recognized in nearly half of patients with advanced disease stages.
The limitation of our study include the absence of detection of HIV tropism to CCR5 and CXCR4 coreceptors
and correlations of HIV tropism with immunological and clinical data of HIV-infected patients involved in the study.
Virus has capacity to use both CCR5 and CXCR4 coreceptors
for attachment and entry into CD4 lymphocytes.
The CCR5 and CXCR4 coreceptors
are required for proper viral entrance to CD4-bearing monocytes and T lymphocytes, by macrophagetropic and lymphotropic vimses, respectively.