CXCR3


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CXCR3

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds CXCL9, CXCL10 and CXCL11; it induces cellular responses involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration.
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Effector cells: CD62L, CD44, CD45RA, CD45RO, CD27, CD28, CD69, Costimulatory molecules CTLA4, ICOS, FAS, PD-1, CD25, CD127, - chemokine receptors CCR7, CCR4, CXCR3, CXCR4, CXCR5, CCR6, CX3CR1, - apoptosis / living dead differentiation annexin, live dye z.
Es aqui donde se describen citocinas como las quimiocinas, que actuan como quimioatrayentes, siendo las primeras en aparecer durante la aposicion, entre las que destaca es la IP-10, observadando la expresion de receptores para IP-10 en el trofoectodermo, como el CXCR3 (Sela et al., 2013).
Increased expression of CXCR3 axis components and matrix metalloproteinase in pediatric inflammatory bowel disease patients.
Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal-conceptus interface in pigs.
Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenerol.
jirovecii tienen activacion de ligandos como CXCL 9-11 y CXCR3 ante la presencia de INF-a in vitro (al activarse la via de Th1) y, posteriormente, ante la presencia de las citocinas proinflamatorias descritas previamente.
CCR5, CCR1, and CXCL4 cause fibrosis, whereas the interaction of CXCL9 and CXCR3 protects against fibrosis (21-23).
Chen et al., "Severe tuberculosis induces unbalanced up-regulation ofgene networks and overexpression of IL-22, MIP-1[alpha], CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-[beta], TIM1, and TLR2 but low antigen-specific cellular responses," The Journal of Infectious Diseases, vol.
Li et al., "Role of the chemokine receptors CXCR3, CXCR4 and CCR7 in the intramuscular recruitment of plasmacytoid dendritic cells in dermatomyositis," Journal of Neuroimmunology, 2018.
CXCL9, IP-10 (CXCL10), and CXCL11 are the ligands of CXCR3. They are chemoattractants of T lymphocytes and NK cells and make contribution in terms of antiviral and antimicrobial [16-18].
Yuda et al., "Angiostatic effect of CXCR3 expressed on choroidal neovascularization," Investigative Ophthalmology & Visual Science, vol.