CXCR3


Also found in: Wikipedia.

CXCR3

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds CXCL9, CXCL10 and CXCL11; it induces cellular responses involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration.
Mentioned in ?
References in periodicals archive ?
2006) CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system.
11,12,13,14] LP is characterised by the upregulation of inflammatory CXCR3 ligands associated with the recruitment of effector cytotoxic T cells and plasmacytoid dendritic cells.
Research published in The American Journal of Pathology shows that one of the protein receptors on white blood cells, CXCR3, brings white blood cells to the optic nerve after damaged nerve tissue produces the binding partner, CXCL10.
Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3.
The objective of this study was to analyze differential expression profiles of CXCR3 and CCL1 genes in M.
In the current study, it was noted that CXCL10 was released from both endothelial and epithelial cells, and it then bound to CXCR3 receptors.
The 10 kDa chemokine interferon-g inducible protein (CXCL-10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects (Liu et al.
CCR5, CXCR3, and CXCR6) but downregulated expression of lymph node-homing molecules (CD62L, CCR7, and CXCR4) [23].
Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo," British Journal of Dermatology, vol.
In addition, the expression of 7 cytokines genes (IL-22, VEGFA, IL26, CXCL14, BMPER, IL-17D, and CCL20) and 16 receptor genes (IL-22RA1, CXCR3, IL-17RC, IL-1RAPL2, IFITM5, NRG2, TNFRSF14, LEPREL2, IL-11RA, LTBP2, ILDR1, IL-17RD, MC1R, IL-22RA2, LEPREL1, and LILRA5) were significantly downregulated by 3.
CXCR3 promotes the production of IgG1 autoantibodies but is not essential for the development of lupus nephritis in NZB/NZW mice.