CXCR3


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CXCR3

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds CXCL9, CXCL10 and CXCL11; it induces cellular responses involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration.
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Distinctive chemokine receptors on Th1 cells include CCR5 and CXCR3 that bind inflammatory chemokines.
Small molecule inhibitors that block CXCR3 and its related chemokines are currently being tested for the treatment of human autoimmune and inflammatory disorders.
88) Other general tumor markers that have been studied extensively include p53, (89) Ki-67, (90) CXCR3 and CXCR4, (91) matrix metalloproteinase 2 or 9, (92) insulin-like growth factor II mRNA-binding protein (IMP3), (93) B7-H1, B7-H3, and B7-H4, (94) and survivin, (95) among others.
Since CXCR3 shares multiple ligands (CXCL4, CXCL9, CXCL10 and CXCL11), the goal of this study was to determine the key role of CXCR3 ligands associated with fatal CM in order to facilitate their development as biomarkerfs) of CM severity.
TLR7 ligation could not induce IFN-[gamma] dependent CXCR3 ligand production in human microvascular endothelial cells (HMVEC) and TLR7 was not expressed on these cells (20).
Chemokine receptors (such as CCR1, CCR2, CCR5, CXCR3, and CXCR4) are expressed by KS spindle cells.
Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system.
San Diego, CA) has patented transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a CXC chemokine receptor subtype 3 (CXCR3), and most particularly to mutated (non-endogenous) version of the human CXCR3 for evidence of constitutive activity and uses thereof.
Both IP-10 and MIG are lymphocyte-targeting CXC chemokines acting on the common receptor CXCR3, and they are produced at high concentrations by activated bronchial epithelial cells in response to infection (31).
Baseline CXCR3 Ligand Levels are Associated With Early Virologic Response to Treatment With Peginterferon Lambda-1a in Chronic Hepatitis C Patients in a Phase 2b Study