CXCR2

CXCR2

A gene on chromosome 2q35 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds IL8, as well as CXCL1, CXCL3, GRO/MGSA and NAP-2. CXCR2 is a potent neutrophil chemotactic factor and mediates neutrophil migration to sites of inflammation; it mediates IL8’s angiogenic effects on intestinal microvascular endothelial cells.
References in periodicals archive ?
C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) pipeline Target constitutes close to 16 molecules.
Tumors with KIR3DL2 mutations expressed low levels of CXCL5 and its receptor CXCR1 and CXCR2, a potential mechanism of resistance to tipifarnib.
CXCL8 is a ligand for CXCR1 and CXCR2 which are secreted by the cancer cells.
Mature neutrophils in the circulation can be rich in various receptors, such as CXCR1, CXCR2, FcI3R (Fc gamma receptor) and other receptors (Russo et al., 2014; Sun et al., 2016) (Fig.
According to the company, the SX-682 is a clinical-stage oral allosteric small-molecule inhibitor of CXCR1 and CXCR2 (CXCR1/2), a combined "master switch" of the immunosuppressive tumour microenvironment.
(2007) Exercise induces interleukin-8 receptor (CXCR2) expression in human skeletal muscle.
have indicated that milk fat globule-EGF factor 8 inhibited neutrophil migration and NETosis through downregulation of CXCR2 expression, resulting in attenuated early inflammatory responses in SLE and reduced tissue damage.[56]
The chemokine, CXCL1, binds to CXCR2 and is expressed by macrophages, neutrophils, and epithelial cells such as gingival fibroblasts [41].
Richmond, "CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways," Molecular Biology of the Cell, vol.
Receptors suchas SSTR, NCA-90, integrins, folate, bombesin, vascular cell adhesion protein-1, and interleukins expressed by activated T-cells, CXCR2 expressed on neutrophils, and CXCR4 overexpressed by leukocytes have demonstrated potential for in vivo targeted imaging [108].
It was noted that these [Gr-1.sup.+] cells lacked myeloperoxidase (MPO) and CXCR2 expression (data not shown); both are markers of mature neutrophils.