CXCR4

(redirected from CXCR-4)

CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.
References in periodicals archive ?
To date, Heptares has applied its GPCR-focused SBDD approach to several other important GPCRs, enabling the assembly of a rich pipeline of novel drug candidates targeting serious neurological (CNS) and metabolic disorders, including: highly selective muscarinic M1 agonists (Alzheimer's disease and cognitive impairment associated with other CNS disorders); dual orexin 1/2 antagonist (chronic insomnia); selective orexin 1 antagonist (addiction and compulsive disorders); allosteric modulators of mGluR5 (autism, Parkinson's disease, depression and anxiety); GLP-1 agonist (Type 2 diabetes); and CXCR-4 antagonists (cancer/HIV).
The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways.
The C-C chemokines RANTES, MIP-1[alpha] and MIP-1[beta] are shown to be the natural ligands for CCR-5 and CXCR-4 receptors.
CXCR-4, CCR-2, and CCR-3) are believed to facilitate infection.
Anderson Cancer Center, Houston, TX, "Cross talk between the B-cell receptor and CXCR-4 chemokine receptors in chronic lymphocytic leukemia: a new role for ZAP-70.
24%) NYTH007 06/26/2003 05:30 r f bc-PA-Auxilium-Testim (NORRISTOWN) Auxilium Receives Regulatory Approval to Market Testim(TM) Testosterone Gel in the United Kingdom SFTH048 06/26/2003 05:30 r f bc-CA-STATS FastRamp(R) Test Services to Showcase New San Diego Operation NYTH052 06/26/2003 05:49 r f bc-WA-NWBT-CXCR-4-tumor (BOTHELL) Northwest Biotherapeutics Identifies CXCR-4 Clinical Antibodies That Inhibit Tumor Cell Division and Metastasis NYTH051 06/26/2003 05:54 r f bc-Thomson-Financial Asian Markets End Mostly Lower After U.
BULLETIN BOARD: NWBT) announced yesterday the completion of its in vitro pre-clinical assessment of a battery of proprietary monoclonal antibodies directed against the cancer associated target CXCR-4.
NWBT scientists were the first to discover that CXCR-4 is over-expressed in cancer.
BOTHELL) Northwest Biotherapeutics Prioritizes CXCR-4 Development
DCTH053 04/05/2001 13:42 r f bc-WA-NW-Biotherapeutics (BOTHELL) Northwest Biotherapeutics Prioritizes CXCR-4 Development