CXCR-3 | definition of CXCR-3 by Medical dictionary
CXCR3 (redirected from CXCR-3)
CXCR3 A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds CXCL9, CXCL10 and CXCL11; it induces cellular responses involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration.
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References in periodicals archive
Chemokine receptor 3 (CXCR-3
) gene product is involved in chemotactic T-cell migration, dendritic cell maturation and recruitment of inflammatory cells during infections (16).
Increased expression of interleukin-15 has been observed ; enhanced intestinal permeability has been also observed , induced by zonulin , whose release is mediated by gluten activated CXCR-3
However, concentrations of 2 non-ELR chemokines, IP-10 and MIG, which act specifically on the CXCR-3
receptor, were not significantly different among the groups (Table 3), suggesting that they were not strongly influenced by the severity of sepsis.