CXCR3

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CXCR3

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds CXCL9, CXCL10 and CXCL11; it induces cellular responses involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration.
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Chemokine receptor 3 (CXCR-3) gene product is involved in chemotactic T-cell migration, dendritic cell maturation and recruitment of inflammatory cells during infections (16).
Increased expression of interleukin-15 has been observed [19]; enhanced intestinal permeability has been also observed [20], induced by zonulin [21], whose release is mediated by gluten activated CXCR-3 [22, 23].
However, concentrations of 2 non-ELR chemokines, IP-10 and MIG, which act specifically on the CXCR-3 receptor, were not significantly different among the groups (Table 3), suggesting that they were not strongly influenced by the severity of sepsis.