CXCR2

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CXCR2

A gene on chromosome 2q35 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds IL8, as well as CXCL1, CXCL3, GRO/MGSA and NAP-2. CXCR2 is a potent neutrophil chemotactic factor and mediates neutrophil migration to sites of inflammation; it mediates IL8’s angiogenic effects on intestinal microvascular endothelial cells.
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References in periodicals archive ?
For example, antagonization of C-X-C motif chemokine receptor 2 (CXCR-2) prevented recruitment of neutrophils to the infarct area [33].
MIF regulate arginase-1 production through a C-X-C-chemokine receptor-2 (CXCR-2)-dependent manner [149].
also demonstrated IL-17's net angiogenic effects on human nonsmall cell lung cancer (NSCLC) cells in immune-compromised mice via CXCL-8 (IL-8) production and its actions on its receptor (CXCR-2) on endothelial cells via selective production of the following angiogenic cytokines: CXCL-1, CXCL-5, CXCL-6, and CXCL-8 [71].
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
Wqgrowska-Danilewicz et al., "Eotaxin (CCL11), TARC [thymus and activation-regulated chemokine (CCL17)], MCP-1 (CCL2) and CCR-1, CXCR-1, CXCR-2 expression in dermatitis herpetiformis and bullous pemphigoid," Archives of Medical Science, vol.