CSF CXCL10, CXCL9
, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis.
The expression patterns of the liver inflammatory cytokines IL10RB and CXCL9
observed in this study were similar to those reported by Pistol et al , in which the expression of pro-and anti-inflammatory cytokines were determined to be dramatically downregulated upon exposure to ZEN-contaminated diet.
Interestingly, the expression of macrophage M1 markers Nos2/ Cxcl9
and M2 marker Tgm2 all increased significantly, with no clear M1/M2 bias.
Chemokines whose concentrations were measured in the present study included CXCL8 (IL-8), CXCL9
(monokine induced by gamma interferon), CXCL10 (interferon-gamma-induced protein 10 [IP-10]), CXCL11 (interferon-inducible T-cell alpha chemoattractant), CCL4 (macrophage inflammatory protein 1[sz] [MIP-1[sz]]), CCL11 (eotaxin-1), CCL26 (eotaxin-3), CCL17 (thymus and activation-regulated chemokine [TARC]), CCL22 (macrophage-derived chemokine [MDC]), CCL2 (monocyte chemoattractant protein 1 [MCP-1]), and CCL13 (MCP-4).
showed that stimulation of gastric epithelial cells by NOD1 ligand induces a robust production of IFN-[beta] and that such type I IFN production leads to a marked production of Th1 chemokines such as CXCL9
, CXCL10, and CXCL11.
BAL (A) IL-5, (B) IL-13, (C) IL-9, (D) CXCL1, (f) IL-6, (F) IL-2, (G) eotaxin (CCL11), (H) CSF3, (I) IL-1a, (J) IL-10, (K IL-12 (p40), (L) CXCL10, (M) LIF, (N) RANTES, (O) CXCL9
, and (P) CCL4 in a cohort of WT and db/db treated with isotype antibody prior to air or [O.sub.3] exposure.
In total of 269 DE genes among the three comparisons, only 8 DE genes overlapped, including Pcdhgb2, Ubd, Ttr, Cxcl9
, Serpina3n, Irg1, Odf1, and Trpv4, but there are few reports of depression associated with these genes, except the Ttr [32, 33].
Intron 1 of the CXCL9
gene (rs2276886) polymorphism may be closely related to pediatric Crohn's disease .
Fallahi, "Increase of interferon-gamma inducible CXCL9
and CXCL11 serum levels in patients with active Graves' disease and modulation by methimazole therapy," Thyroid, vol.
When IFN type 1 is activated, it induces production of various inflammatory chemokines, including CXCL9
and CXCL10, recruits chemokines such as CLA, E-selectin, CCR4, and CXCR3 to diseased skin, and causes local inflammation .
In this case, several genes involved in cross talks between immune cells and cancer cells, such as C-C motif chemokine ligand 4 (CCL4), C-X-C motif chemokine ligand 2 (CXCL2), CXCL9
, interleukin 15 (IL15), IL1B, or IL8 showed different expression levels between the individual CTCs captured via EpCAM or by size (see online Supplemental Fig.
We assessed protein levels of 22 cytokines and chemokines associated with innate and adaptive immune responses (innate: TNF, IL-1[beta], IL-6, IL-10, granulocyte-macrophage colony-stimulating factor, IL-8, IFN-[alpha], CCL2, CCL3, and CCL19; adaptive-Thl: IFN-[gamma], IL-12p40, IL-12p70, cysteine-X-cysteine motif cytokine ligand 9 (CXCL9
), and CXCL10; adaptive-Th17: IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, and IL-27) in culture supernatants by using bead-based Luminex (EMD-Millipore, Darmstadt, Germany) multiplex assays.