CXCL9


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Related to CXCL9: CXCL10, CXCL11

CXCL9

A gene on chromosome 4q21 that encodes a cytokine that affects the growth, movement or activation of cells that participate in  immune and inflammatory responses. It is thought to be involved in T-cell trafficking.
References in periodicals archive ?
The concentrations of CXCL9 and CXCL11 in BALF were determined using commercial ELISA kits (R&D System, Inc.
As expected, these studies disclosed that a number of prototypical pro-inflammatory factors are produced in the chronic pancreatic tissue including TNF-[alpha], IL-6, IFN-[gamma], and IFN-[beta] among the cytokines and CCL2, CXCL9 and CXCL10 among the chemokines.
Mouse CCL4, CXCL9, and CXCL10 are lyophilized, available in convenient sizes (5 and 25 micrograms) and in-stock ready to ship.
Urine tests revealed that patients with high CXCL9 had a tripled likelihood of rejection compared with those with low readings.
Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group.
Thus MDSCs and, in particular, immature macrophages and DCs may participate in the inhibition of CD4+ and CD8+ T cells and the inhibition of their potential anti-angiogenic effect mediated by the type 1 cytokines IFN[gamma], CXCL10 and CXCL9.
In established cutaneous LE lesions, the CXCR3 ligands CXCL9 (interferon-gamma [IFN[gamma]]-induced monokine), CXCL10 (IFN[gamma]-inducible protein 10), and CXCL11 (IFN-inducible T cell alpha chemoattractant) are the most abundantly expressed chemokine family members.
Targeted inflammatory mediators and cell types affected by the pluripotent mechanism of action of apremilast include: inhibition of production of TNF-a, IFN-g, IL-12, IL-23, IL-2, IL-5, IL-17, CXCL9 (MIG), CXCL10 (IP-10), CCL2 (MCP-1), CCL3 (MIP-1a), IL-8, LTB4, and iNOS; inhibition of activation of T and NK cells, monocytes, dendritic cells, synovial macrophages, neutrophils, chondrocytes, keratinocytes, and endothelial cells; as well as, the unique inhibition of joint pannus formation and cartilage erosion.
SERPINE1, ICAM1, F3, MMP3, CCL2, CXCL5, CXCL9, and VCAM1; and CD69, PLAU, PLAT, SELP, SELE, HLA-DRA, IL1 A, PLAUR, SAA1, TIMP2, CCL26, TGFB1, NR4A2, CSF1, and CXCL10: tissue remodeling during inflammation and angiogenesis
Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome," Investigative Ophthalmology and Visual Science, vol.
4,32) De estas sustancias, las que participan en la inmunopatogenesis de la psoriasis incluyen CCL17, CXCL9 (monoquina inducida por interferon [gamma]), CXCL10, CCL22, CCL5, CCL27 (quimioquina atrayente de la celula T cutanea), CCL20 (proteina inflamatoria del macrofago), CCL19 y CXCL8 (quimioquina atrayente del neutrofilo).