IL8

(redirected from CXCL8)

IL8

A gene on chromosome 4q13-q21 that encodes interleukin-8, a cytokine belonging to the CXC chemokine family. IL8 is a major mediator of inflammation, acting as a chemoattractant for neutrophils, basophils and T-cells, and is a potent angiogenic factor.

Molecular pathology
IL8 is a candidate gene for bronchiolitis.
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References in periodicals archive ?
Finally, NSCLC cells can express CXCL8 which takes on an important role as a growth factor with autocrine/paracrine action on tumor cells.
Hemodialysis, Chronic renal failure (CRF), Neutrophils, CXCL8, Micro inflammatory reaction.
Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation.
(64) and CSF CXCL1, CXCL8, CXCL10, CXCL13, CCL20, CCL22, NfL, NfH, GFAP, chitinase-3-like-1 MMP-9, osteopontin levels in RIS and RRMS cases Petzold (65) Relationship between CSF NfH values and clinical EDSS Petzold et al.
The latter is important, as proteins previously identified as potential biomarkers for endometriosis such as the chemokines CXCL8, CCL2, and CCL5 vary during the menstrual cycle which practically limits their diagnostic value.[4] It would have been interesting and helpful if the authors combined CEC and CA125 as a panel of biomarkers to assess whether the combination had increased diagnostic value compared to CEC alone.
Troosters et al., "Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I," Thorax, vol.
Serum IL-8 (CXCL8) levels were significantly elevated in CRC patients and those with other cancers [20-22].
Christmas, "Induction of IL-8 (CXCL8) and MCP-1 (CCL2) with oxidative stress and its inhibition with N-acetyl cysteine (NAC) in cell culture model using HK-2 cell," Transplant Immunology, vol.
Actually, knockdown of IL-1[beta]-eRNA or IL1[beta]-BT46 selectively attenuates LPS-induced production of the proinflammatory factors, such as IL-1[beta] and CXCL8.
Production of IL-6 is increased in the late passage human bone marrowderived MSC compared to early passage cells, whilst CXCL8 levels fall [41].
(iii) IL-8 was measured with a Human CXCL8 Quantikine kit (Bio-Techne Ltd., 614 McKinley Place NE, Minneapolis, MN 55413, USA) (kit serial number D8000C).