PF4

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PF4

A gene on chromosome 4q12-q21 that encodes a protein released from the alpha-granules of activated platelets which binds with high affinity to heparin. PF4’s major physiologic role appears to be neutralisation of heparin-like molecules on the endothelial surface of blood vessels, inhibiting antithrombin-III activity and promoting coagulation; as a chemoattractant for neutrophils and fibroblasts, PF4 likely plays a role in inflammation and wound repair.
References in periodicals archive ?
2005) CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production.
CXCL4 es uno de los genes mas diferenciados y expresados en los estudios genomicos de ES y codifica para una proteina relacionada con los megacariocitos con un potente efecto antiangiogenico; su hallazgo puede incluso predecir la progresion de la enfermedad pulmonar (30).
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis.
Secondly, CXCL4 was found to be closely associated with disease severity and implicated in key immune defects that recapitulate SSc.
23 December 2013 - A research team from the Boston University School of Medicine and their colleagues have discovered that levels of CXCL4 in systemic sclerosis patients may predict progression in systemic sclerosis phenotypes and that it correlates with skin and pulmonary disease.
In laboratory studies, the protein, called CXCL4 or PF-4, binds to HIV such that it cannot attach to or enter a human cell.
Immune complexes formed following the binding of anti-platelet 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion.
9:15 CXCL4 AND CXCL10 PREDICT RISK OF FATAL CEREBRAL MALARIA,
It has been shown in vitro that angiostatic factors, such as thrombospondin-1 and the chemokines CXCL4 and CXCL14, appear to enhance DC maturation and APC function.
PF4, also known as CXCL4, is a polypeptide constituent of platelet alpha granules that is released during platelet aggregation and inhibits heparin-mediated reactions.
9:15 CXCL4 AND CXCL10 PREDICT RISK OF FATAL CEREBRAL MALAR-IA, Nana Wilson * (1), Vidhan Jain (2), Christina Roberts * (3), Naomi Lucchi (3), Pradeep Joel5, Mrigendra P.
One of them (7765 Da) was subsequently identified as PF4, which is a CXCL4 chemokine expressed in various inflammation cell types (29) as well as metastatic prostate cancer cells (30) and megakaryoblastic leukemia cells (31).