A gene on chromosome 5q31 that encodes a CXC-type chemokine that is a potent chemoattractant for neutrophils, and weaker one for dendritic cells. It is not chemotactic for T cells, B cells, monocytes, natural killer cells or granulocytes.
Expression of CXCL1, CXCL2, CXCL3, CXCL5, CXCL7, and CXCL14 in liver, lung, kidney, adipose, spleen, and thymus of C57BL/6 mice wt and AhRR Tg male mice in response to TCDD.
of bp upstream of Gene DREs coding sequence CXCL1 3 -1,305; -309; -290 CXCL2 1 -168 CXCL3 1 -3,236 CXCL5 7 -2,537; -1,830, -1,818; -1,810; -1,802; -1,794; -1,786 CXCL7 1 -2,339 CXCL10 3 -2,509; -2,472; -1,448 CXCL14 1 -30 IL-1P 1 -495 IL-6 1 -398 IL-10 1 -335 IL-22 1 -1,082 DRE consensus sites within the promoter region of the cytokines were analyzed using the TFSEARCH program (Heinemeyer et al.
In contrast to ALK+ ALCL, there was also lower expression of cytotoxic molecules, cathepsins, and Th17 cell-associated molecules, and higher expression of some cytokines/receptors (CCL1, CCL22, CCR8, CCR4, IL-13RA2, CXCL14, TGF-bR1) and antiapoptotic molecules (BCL2, BIRC6, BIC), and lower expression of some proapoptotic genes (BAX, BCL2L1, BNPIP3).
In contrast, the chemokine CXCL14, which is abundantly expressed in normal tissue but downregulated in breast cancer tissue and cell lines, negatively regulates the growth and metastasis of breast cancer as its expression is positively associated with patient survival and a lower incidence of metastasis.
Angiostatic CXC chemokine family members include CXCL4, CXCL9, CXCL10, CXCL11, and CXCL14. CXCL4, CXCL9, and CXCL10 signal through CXCR3, which, on ligand engagement, blocks microvascular endothelial cell migration and proliferation (Figure 2) in response to various angiogenic factors .