CXCL13


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CXCL13

A gene on chromosome 4q21 that encodes a CXC-type chemokine strongly expressed in the follicles of the spleen, lymph nodes and Peyer's patches, which acts as a homing signal for B cells by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1).
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References in periodicals archive ?
In case of biomass smoke exposure, higher levels of CCL15, CCL27, and CXCL13 were detected in the BMSCONTROL group compared to the BMS-COPD subgroup.
Hence, the HEV basal lamina binds locally produced lymphoid chemokines, including CCL21, CCL19, CXCL12, and CXCL13, creating a chemokine-rich environment.
miR-567 SPTBN1; DUSP1; BCHE; LPHN2 miR-141-3p H3F3B; TCEAL2; MYH10; LHFP; LPHN2; CCL2; KLF9 miR-454-3p DPYSL2; HOXA5; FKBP11; SRPX; EDN1; LDLR; CAV2; BMPR2; SLC2A1 SERPINE2; PLEKHC1; SPTBN1; H3F3B; miR-590-3p TMEM47; TIMP3; COL3A1; CXCL13; ETS2; CELSR3; LPL; SMAD6; BMPR2; LPHN2; SASH1.
To further substantiate the LNB diagnosis, we determined the B-cell attractant chemokine CXCL13 from CSF.
A third approach is to target lymphoneogenesis more generally by interfering with the production of the chemokines CXCL13 and CXCL12.
Among the genes that were significantly down regulated in the meta-gene expression signature, Interleukin 1 receptor-like 1 (Il1rl1), Synaptosomal-associated protein 25 (Snap25), Chemokine (C-C motif) ligand 11 (Ccl11), Chemokine (C-X-C motif) ligand 13 (Cxcl13), Flavin containing monooxygenase 1 (Fmo1) were found to be important.
Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine.
Recent studies revealed that Snail played an important role in chemoresistance [25], further, it was also reported that chemokines such as CXCL13 treatment can upregulate the expression of Snail in cancer cells and induce EMT [26].
Increasing interest is developing in early detection of relapse for timely management with the help of biomarkers such as CXCL13 (BCA-1), matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinases-1(TIMP-1).8
The expression of 15 cytokines genes (ADIPOQ, BMP2K, CCL3, CXCL13, IL-16, IL-28B, IL-34, SPP1, TGFB1, TNFAIP2, TNFAIP3, TNFAIP8, TNFAIP8L1, TNFSF11, and TNFSF13B) was significantly upregulated by 2.1- to 9.25-fold (Supplementary Table S4, Figure 4), while 46 cytokine receptors (CSF3R, CXCR7, IL-17RA, IL-18R1, IL-1R1, IL-1R2, IL-20RA, IL-21R, IL-2RG, IL-4I1, IL-5RA, IL-7R, IL-9R, LILRB3, TGFBR1, TLR1, TLR15, TLR21, TLR5, TLR6, TLR7, TNFRSF13B, TNFRSF13C, TNFRSF1B, TRAT1, XCR1, etc.) were also significantly upregulated by 2.04- to 10.16-fold in chicken line 6.3 with p < 0.01 and fold [greater than or equal to] 2 (Supplementary Table S4, Figure 5).