Hence, the HEV basal lamina binds locally produced lymphoid chemokines, including CCL21, CCL19, CXCL12, and CXCL13
, creating a chemokine-rich environment.
Among the genes that were significantly down regulated in the meta-gene expression signature, Interleukin 1 receptor-like 1 (Il1rl1), Synaptosomal-associated protein 25 (Snap25), Chemokine (C-C motif) ligand 11 (Ccl11), Chemokine (C-X-C motif) ligand 13 (Cxcl13
), Flavin containing monooxygenase 1 (Fmo1) were found to be important.
The expression of 15 cytokines genes (ADIPOQ, BMP2K, CCL3, CXCL13
, IL-16, IL-28B, IL-34, SPP1, TGFB1, TNFAIP2, TNFAIP3, TNFAIP8, TNFAIP8L1, TNFSF11, and TNFSF13B) was significantly upregulated by 2.1- to 9.25-fold (Supplementary Table S4, Figure 4), while 46 cytokine receptors (CSF3R, CXCR7, IL-17RA, IL-18R1, IL-1R1, IL-1R2, IL-20RA, IL-21R, IL-2RG, IL-4I1, IL-5RA, IL-7R, IL-9R, LILRB3, TGFBR1, TLR1, TLR15, TLR21, TLR5, TLR6, TLR7, TNFRSF13B, TNFRSF13C, TNFRSF1B, TRAT1, XCR1, etc.) were also significantly upregulated by 2.04- to 10.16-fold in chicken line 6.3 with p < 0.01 and fold [greater than or equal to] 2 (Supplementary Table S4, Figure 5).