CXCL13


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CXCL13

A gene on chromosome 4q21 that encodes a CXC-type chemokine strongly expressed in the follicles of the spleen, lymph nodes and Peyer's patches, which acts as a homing signal for B cells by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1).
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Cerebrospinal fluid CXCL13 in multiple sclerosis: A suggestive prognostic marker for the disease course.
Hence, the HEV basal lamina binds locally produced lymphoid chemokines, including CCL21, CCL19, CXCL12, and CXCL13, creating a chemokine-rich environment.
In recent years, CXCL13 has been identified as a potentially sensitive and specific biomarker for diagnosing acute LNB.
Similarly, the expression of 18 cytokine genes (IL-7, IL-10, TNFAIP8, SPP2, TNFAIP3, IFNB, CCL19, TNFAIP8L1, IL-16, CNTF, CXCL13, TNFAIP8L3, TNFSF13B, IL-34, TGFB1, TNFAIP2, CCL3, and ADIPOQ) and 39 cytokine receptor genes (CXCR7, CSF2RA, IL-1RL1, I-L1R2, IL-17RA, IFNAR1, IL-18RAP, IL-31RA, IL-9R, IL-18R1, IL-20RB, IL-21R, IL-2RG, IL-20RA, IL-4I1, LILRB1, TLR1, IL-17REL, LILRB5, TGFBR1, TLR6, TNFRSF13B, XCR1, TLR7, TNFRSF13C, TLR15 etc.
The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis CSF CXCL13 and can be used as a diagnostic marker for infection.
Nuevos marcadores para detectar la neurosifilis asintomatica en pacientes con HIV se han desarrollado, como por ejemplo la deteccion de la citocina CXCL13 de los linfocitos B en el LCR, se continua trabajando para perfeccionar este metodo, que permitiria encontrar un marcador realmente especifico para esta poblacion tan dificil de diagnosticar.
Las quimioquinas CXCL12, CXCL13 atraen a las celulas B y han sido identificadas en las celulas B malignas del LPSNC.
Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony stimulating factor.
The qPCR primers and hydrolysis probes for the genes CALM2 [calmodulin 2 (phosphorylase kinase, delta)], CHPT1 (choline phosphotransferase 1), CXCL13 [chemokine (C-X-Cmotif) ligand 13], ERBB2 [v-erbb2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)], ESR1 (estrogen receptor 1), IGKC (immunoglobulin kappa constant), MLPH (melanophilin), MMP1 [matrix metallopeptidase 1 (interstitial collagenase)], OAZ1 (ornithine decarboxylase antizyme 1), PGR (progesterone receptor), RAC-GAP1 (Rac GTPase activating protein 1), RPL37A, TOP2A [topoisomerase (DNA) II alpha 170kDa], and UBE2C (ubiquitin-conjugating enzyme E2C) were identified with Primer Express[TM] software (Applied Biosystems) according to the manufacturer's instructions.
CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma.
42, CXCL13, and D2-40) rather than sole markers should be included in the immunostaining, as IPT-like FDC tumors often show only focal or weak FDC marker immunopositivity.