CXCL13


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CXCL13

A gene on chromosome 4q21 that encodes a CXC-type chemokine strongly expressed in the follicles of the spleen, lymph nodes and Peyer's patches, which acts as a homing signal for B cells by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1).
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In case of biomass smoke exposure, higher levels of CCL15, CCL27, and CXCL13 were detected in the BMSCONTROL group compared to the BMS-COPD subgroup.
Hence, the HEV basal lamina binds locally produced lymphoid chemokines, including CCL21, CCL19, CXCL12, and CXCL13, creating a chemokine-rich environment.
miR-567 SPTBN1; DUSP1; BCHE; LPHN2 miR-141-3p H3F3B; TCEAL2; MYH10; LHFP; LPHN2; CCL2; KLF9 miR-454-3p DPYSL2; HOXA5; FKBP11; SRPX; EDN1; LDLR; CAV2; BMPR2; SLC2A1 SERPINE2; PLEKHC1; SPTBN1; H3F3B; miR-590-3p TMEM47; TIMP3; COL3A1; CXCL13; ETS2; CELSR3; LPL; SMAD6; BMPR2; LPHN2; SASH1.
To further substantiate the LNB diagnosis, we determined the B-cell attractant chemokine CXCL13 from CSF.
A estos FALCs se les relaciona con la retencion de linfocitos B1 en la cavidad peritoneal por la alta expresion de CXCL13 (Ligando 13 de la familia de quimiocinas CXC) tambien conocida como quimio atrayente de linfocitos B.
A third approach is to target lymphoneogenesis more generally by interfering with the production of the chemokines CXCL13 and CXCL12.
Among the genes that were significantly down regulated in the meta-gene expression signature, Interleukin 1 receptor-like 1 (Il1rl1), Synaptosomal-associated protein 25 (Snap25), Chemokine (C-C motif) ligand 11 (Ccl11), Chemokine (C-X-C motif) ligand 13 (Cxcl13), Flavin containing monooxygenase 1 (Fmo1) were found to be important.
Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine.
Recent studies revealed that Snail played an important role in chemoresistance [25], further, it was also reported that chemokines such as CXCL13 treatment can upregulate the expression of Snail in cancer cells and induce EMT [26].
Increasing interest is developing in early detection of relapse for timely management with the help of biomarkers such as CXCL13 (BCA-1), matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinases-1(TIMP-1).8
The expression of 15 cytokines genes (ADIPOQ, BMP2K, CCL3, CXCL13, IL-16, IL-28B, IL-34, SPP1, TGFB1, TNFAIP2, TNFAIP3, TNFAIP8, TNFAIP8L1, TNFSF11, and TNFSF13B) was significantly upregulated by 2.1- to 9.25-fold (Supplementary Table S4, Figure 4), while 46 cytokine receptors (CSF3R, CXCR7, IL-17RA, IL-18R1, IL-1R1, IL-1R2, IL-20RA, IL-21R, IL-2RG, IL-4I1, IL-5RA, IL-7R, IL-9R, LILRB3, TGFBR1, TLR1, TLR15, TLR21, TLR5, TLR6, TLR7, TNFRSF13B, TNFRSF13C, TNFRSF1B, TRAT1, XCR1, etc.) were also significantly upregulated by 2.04- to 10.16-fold in chicken line 6.3 with p < 0.01 and fold [greater than or equal to] 2 (Supplementary Table S4, Figure 5).