Similarly, the expression of 18 cytokine genes (IL-7, IL-10, TNFAIP8, SPP2, TNFAIP3, IFNB, CCL19, TNFAIP8L1, IL-16, CNTF, CXCL13, TNFAIP8L3, TNFSF13B, IL-34, TGFB1, TNFAIP2, CCL3, and ADIPOQ) and 39 cytokine receptor genes (CXCR7, CSF2RA, IL-1RL1, I-L1R2, IL-17RA, IFNAR1, IL-18RAP, IL-31RA, IL-9R, IL-18R1, IL-20RB, IL-21R, IL-2RG, IL-20RA, IL-4I1, LILRB1, TLR1, IL-17REL, LILRB5, TGFBR1, TLR6, TNFRSF13B, XCR1, TLR7, TNFRSF13C, TLR15 etc.
Of those analyzed, the gene expression levels of 7 genes (IL-16, LILRB3, CXCL13, IL-7R, LILRB5, TLR21, and TNFAIP2) were higher in chicken line 6.
Cytokines with chemoattracting activity found in colostrum or milk for the 1st time included PARC/CCL18, MIP-3[alpha]/CCL20 (mainly for lymphocytes and immature dendritic cells), MIP-1[beta]/CCL4 (mainly for NK cells and macrophages), and B lymphocyte chemoattractant/ CXCL13
(mainly for naive B lymphocytes).
At the National Eye Institute, examination of retinal tissues from 2 enucleated eyes, an eye found to be normal on autopsy, and a chorioretinal biopsy from 3 patients with PIOL found that RPE cells infiltrated by PIOL had a lower expression of CXCL12 and CXCL13
compared with those adjacent RPE cells not yet invaded.