Based upon molecular characterization of the initial patients, the Phase 2 trial was amended to include two expansion cohorts: 1) patients with AITL, an aggressive form of T-cell lymphoma often characterized by high levels of CXCL12
expression, and 2) patients with PTCL who lack a single nucleotide variation in the 3'-untranslated region of the CXCL12
Stromal cell-derived factor 1 (SDF-1, CXCL12
) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti-inflammatory agents.
The effect of CXCR4-C-X-C motif chemokine ligand 12 (CXCL12
) is significant in the metastasis in patients with NSCLC.
"We found that mixing the immunerepellent protein CXCL12
into the capsule gel prevents this overgrowth from happening, prolonging the survival and function of the cells."
RNA analysis in ESBC and HNSCC revealed concordant increases in cytokine gene expression, including CXCL2, CCL4, CXCR4, and CXCL12
as well as transcription factors including FOS, ETS1, NF?B, EGR1/2 which are involved in T-cell activation and differentiation.
Among these chemokines are CXCR4 and CXCL12
, which are critical to the attachment of blood cancer cells to the protective bone marrow environment and platelet factor 4, which slows bone marrow recovery after chemotherapy.
Similarly, sema3A was also found to be involved in the regulation of human thymocyte migration and proven to inhibit triggered chemotaxis by CXCL12
expression has been proposed as a prognostic marker and validated in two data sets.
[ELR.sup.-] chemokines are commonly angiostatic, but CXCL12
(previously known as stromal cell-derived factor 1, abbreviated as SDF1)  and its receptor, CXCR4 (previously known as LESTR, fusion, or CD184), are reported to promote angiogenesis and play a major role in metastasis.
Weber, "MIF and CXCL12
in cardiovascular diseases: functional differences and similarities," Frontiers in Immunology, vol.
Osseous marrow stromal cells and osteoblasts secrete many chemokines including CXCL12
, which attracts CXCR4 positive BrCa cell homing and colonization to the bone.