CXCL11


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CXCL11

A gene on chromosome 4q21 that encodes a CXC-type chemokine that is chemotactic for IL-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. CXCL11 induces calcium release in activated T-cells, binds to CXCR3 and may play an important role in CNS diseases involving T-cell recruitment. It may also play a role in cutaneous immune responses.
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We also found that the endometrial expression of LIFR was greatest on day 15 of pregnancy, when the implanting conceptus produces the large amounts of cytokines such as interferons (IFNs), IFN-[gamma], and IFN-[delta] [25], and the endometrium produces cytokines and chemokines such as cysteine-X-cysteine motif chemokine ligand (CXCL) 9, CXCL10, and CXCL11 [29].
The involvement of CXCL11 in bone marrow-derived mesenchymal stem cell migration through human brain microvascular endothelial cells.
found that Th17 induced the expression of CXCl9, CXCL10, and CXCL11 chemokines, recruits IFN[gamma]-producing cells, and thus ultimately restricts the reproduction of mycobacteria in macrophage in BCG vaccination model [16].
IFN-[gamma] strongly activates the transcription of the chemokines CXCL9, CXCL10, and CXCL11 [35, 36].
(10,42,64) This was initially discovered by Watanabe et al., who found that gastric and colon cancer cell lines produced a large amount of chemokines upon stimulation with NOD1 ligand and that these included chemokines with the C-X-C motif (CXCL9, CXCL10, and CXCL11) that are dependent on type I IFN responses.
(5) In TB disease, Th17 primarily exerts its protective effect through IL-17, which recruits neutrophils to promote granuloma formation, (6) and increases the expression of chemokines, CXCL9, CXCL10, and CXCL11, which recruit IFN-[gamma] producing cells to the infected site.
Interleukins [interleukin 8 (IL8), interleukin 6 signal transducer (IL6ST), interleukin 7 (IL7), interleukin 15 (IL15), and interleukin 1 receptor type 1 (IL1R1)] and chemokines [C-X-C motif chemokine ligand 2 (CXCL2), C-X-C motif chemokine ligand 6 (CXCL6), C-X-C motif chemokine ligand 10 (CXCL10), C-X-C motif chemokine ligand 11 (CXCL11), C-C motif chemokine ligand 5 (CCL5), and C-C motif chemokine ligand 28 (CCL28)] also were overexpressed in HT-29 cells.
Fallahi, "Increase of interferon-gamma inducible CXCL9 and CXCL11 serum levels in patients with active Graves' disease and modulation by methimazole therapy," Thyroid, vol.
Here in our study, we aim to explore the effect of antiviral treatment of CHC patients with DAAs on the frequency of monocytes (classic [CD14.sup.++][CD16.sup.-] monocytes and inflammatory [CD14.sup.+][CD16.sup.+] monocytes) [18], NK cells ([CD3.sup.-][CD16.sup.+][CD56.sup.+]) [19], and cytokines IL-12, IL-18, CXCL10, and CXCL11, which are necessary to activation of NK cells, and soluble CD14 (sCD14) and soluble CD163 (sCD163), which reflect monocytes activation.
Chung, "Loss of RUNX3 expression promotes cancer-associated bone destruction by regulating CCL5, CCL19 and CXCL11 in non-small cell lung cancer," The Journal of Pathology, vol.
to 0.5 kg for 70 kg adult) Effect of apple PP APP at 1% added to APP administration (APP) on mice with drinking water (90% dampened mRNA induced colitis tannins) for up to 4 expression of IL- weeks [beta], TNF- [alpha], IL-6, IL- 17, IL-22, CXCL9, CXCL10, CXCL11, & IFN-[gamma] in colon Effect of ellagic acid 6 weeks with either MPO activity & TNF- (EA) & enriched 250 or 500 mg/kg PE, [alpha] levels were pomegranate extract or 10 mg/kg EA, or significantly (PE) in TBNS induced both together reduced in rats rats receiving PP Effect of EGCG & Piper 6.9 mg/kg bw.