CXCL11


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CXCL11

A gene on chromosome 4q21 that encodes a CXC-type chemokine that is chemotactic for IL-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. CXCL11 induces calcium release in activated T-cells, binds to CXCR3 and may play an important role in CNS diseases involving T-cell recruitment. It may also play a role in cutaneous immune responses.
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The involvement of CXCL11 in bone marrow-derived mesenchymal stem cell migration through human brain microvascular endothelial cells.
showed that stimulation of gastric epithelial cells by NOD1 ligand induces a robust production of IFN-[beta] and that such type I IFN production leads to a marked production of Th1 chemokines such as CXCL9, CXCL10, and CXCL11.
10) Thus, NOD1 activation of CXCL9, CXCL10, and CXCL11 transcription via type I IFN requires nuclear translocation of ISGF3, a complex composed of Stat1, Stat2, and IRF9.
5) In TB disease, Th17 primarily exerts its protective effect through IL-17, which recruits neutrophils to promote granuloma formation, (6) and increases the expression of chemokines, CXCL9, CXCL10, and CXCL11, which recruit IFN-[gamma] producing cells to the infected site.
2005) 2 Induction of alterations in gene expression: Decrease in E-cadherin Activation of JNK, increased HEF1, also known as NEDD9 and CAS-L 2 HMOX CASP-3 VEGF-MMPs- IL-8 CXCL 10, CXCL11 2 SIRT family (Huang et al.
5 kg for 70 kg adult) Effect of apple PP APP at 1% added to APP administration (APP) on mice with drinking water (90% dampened mRNA induced colitis tannins) for up to 4 expression of IL- weeks [beta], TNF- [alpha], IL-6, IL- 17, IL-22, CXCL9, CXCL10, CXCL11, & IFN-[gamma] in colon Effect of ellagic acid 6 weeks with either MPO activity & TNF- (EA) & enriched 250 or 500 mg/kg PE, [alpha] levels were pomegranate extract or 10 mg/kg EA, or significantly (PE) in TBNS induced both together reduced in rats rats receiving PP Effect of EGCG & Piper 6.
Expressed gene sequence and bioactivity of the IFN-gamma-response chemokine CXCL11 of swine and cattle.
It has also been shown that the overexpression of MIG, IP-10, and CXCL11 in the local tumor inhibits tumor growth and metastasis through the angiostatic effect or activation of T lymphocytes or NK cells(39).
We identified 7 novel biomarkers as statistically significant in discriminating protein concentrations in blood from men with advanced prostate cancer compared to controls: APOC1, ASPN, COMP, CXCL11, CXCL9, F5, and PCSK6.
CXCL11 attenuates bleomycin-induced pulmonary fibrosis via inhibition of vascular remodeling.
In established cutaneous LE lesions, the CXCR3 ligands CXCL9 (interferon-gamma [IFN[gamma]]-induced monokine), CXCL10 (IFN[gamma]-inducible protein 10), and CXCL11 (IFN-inducible T cell alpha chemoattractant) are the most abundantly expressed chemokine family members.
Methods: Meso scale discovery system and commercial ELISA kits were used to measure the concentrations of proinflammatory cytokines interleukin (IL)-1[sz]; tumor necrosis factor-alpha (TNF-a); IL-6; and IL-17 and CC and CXC chemokines CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 and CXCL8, CXCL9, CXCL10, and CXCL11 in bronchoalveolar lavage fluid of asthmatics and controls.