CXCL10


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CXCL10

A gene on chromosome 4q21 that encodes a CXC-type chemokine that is the ligand for CXCR3, which, once bound, stimulates monocyte, natural killer and T-cell migration, and modulation of adhesion molecule expression.
References in periodicals archive ?
sup][1],[2] Although increased evidence have implicated that asthma is a Th2-type inflammatory disorder,[sup][1],[2] other mediators including proinflammatory cytokines interleukin-1 (IL-1), IL-6, IL-17, and tumor necrosis factor-alpha (TNF-a) and various chemokines such as CXC and CC chemokines CXCL8, CXCL10, CCL2, CCL4, CCL11, and others may also participate in the pathogenesis of asthma, through acting directly or indirectly on the target cells.
Then, in studies focused on the origin of NOD1-induced CXCL10 production, Watanabe et al.
BAL (A) IL-5, (B) IL-13, (C) IL-9, (D) CXCL1, (f) IL-6, (F) IL-2, (G) eotaxin (CCL11), (H) CSF3, (I) IL-1a, (J) IL-10, (K IL-12 (p40), (L) CXCL10, (M) LIF, (N) RANTES, (O) CXCL9, and (P) CCL4 in a cohort of WT and db/db treated with isotype antibody prior to air or [O.
Moreover, CXCL1 and CXCL10 were key effectors on this malignant transformation [89].
An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass.
Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo," British Journal of Dermatology, vol.
Urinary Chemokines CXCL9 and CXCL10 are non-invasive markers of renal allograft rejection and BK viral infection.
Los factores de transcripcion activados se traslocan del citoplasma al nucleo, donde se unen a los promotores de sus genes blanco (IFNs, TNF, AIP3, CXCL10, CCL5, SElE, IFIT1-IFIT2) e inducen su transcripcion.
Moreover, 1,25-dihydroxycholecalciferol was shown to significantly diminish production of TNF-[alpha], IL-6, IL-8 and CXCL10 in LPS-stimulated
Nuestro analisis de expresion global con microarreglos revelo diferencias significativas en la expresion de quimiocinas CXCL- y CCL- tales como CXCL1 (Gro-[alfa]), CXCL2 (Gro-[beta]), CXCL5 (ENA-78), CXCL8 (IL-8) y CXCL10 (IP-10).
Increased expression of the chemokine receptor CXCR3 and its ligands CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease.