CXCL1


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Related to CXCL1: CX3CL1, CXCL10, CXCL2, CXCL5

CXCL1

A gene on chromosome 4q21 that encodes a chemokine which, as a group, are involved in cell trafficking of leukocytes through interactions with 7-transmembrane and G protein-coupled receptors, and play critical roles in the development, homeostasis and function of the immune system. Chemokines are also involved in CNS and endothelial cell activity.
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We found that Il6 (Figure 4(e)) and Ccl2 (Figure 4(f)) levels are significantly downregulated in the [CB.sub.2] knockout lungs (p < 0.05), while Cxcl1 displayed a nonsignificant reduction trend (Figure 4(g)).
Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia
For IL-6, CCL2, CCL20, CCL27, CXCL1, and IL1a quantification in culture supernatant, ELISA reagents were used in accordance with the manufacturer's specifications.
Saliva-Derived Host Defense Peptides Histatinl and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1[alpha]-Independent Manner
The module-related DEGs in the PI3K/Akt (namely, LPAR1, COL5A1, and COL6A2) and TNF signaling pathway (termly CXCL1, CXCL2, and CXCL3) were selected to investigate the effect of melittin on them in BC cells.
Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer
ASC CM from an obese patient was depleted of IL6, PAI1, and CXCL1 by incubation with neutralizing antibodies against the three factors (described above) at 4[degrees]C overnight with constant rotation.
Adipose Tissue-Secreted Factors Alter Bladder Cancer Cell Migration
Phosphorylation of IKKi and binding of TRAF2 and TRAF5 lead to CXCL1 chemokine stabilization to drive neutrophil recruitment, whereas binding of TRAF6 leads to activation of mitogen-activated protein kinase (MAPK) and transforming growth factor b activated kinase-1 (TAK1), to induce translocation and transcriptional activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-[kappa]B) activator protein (AP-1), CCAAT-enhancer-binding protein (C/EBP) and NF-[kappa]B (25-27).
Targeting IL-17 in psoriatic arthritis
(35) Finally, it should be mentioned that NOD1-deficient mice are more susceptible to Clostridium difficile infection which in this case was attributed to decreased neutrophil recruitment occurring as a result of decreased epithelial cell C-X-C motif chemokine ligand 1 (CXCL1) production.
Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders
Gene expression analysis showed significant upregulation of pro-inflammatory cytokines (TNF-[alpha] and IL-6) and chemokines (MCP-1 and CXCL1) in MEHP-treated cells on Day 16, albeit to a lesser extent than the positive control TNF-[alpha] (Figure 2A).
Monoethylhexyl phthalate elicits an inflammatory response in adipocytes characterized by alterations in lipid and cytokine pathways
A total of 7 ego genes were obtained, IL1B (z-score=2.41), IL1A (z-score=2.14), NLRP3 (z-score=2.08), TNF (z-score=2.04), PTGS2 (z-score=1.73), CXCL1 (z-score=1.42), and CSF2 (z-score=1.35) (Table 1).
Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis
These include CXCL1 (Gro-[alpha]), CCL2, CCL7 (MCP-1, MCP-3), and CCL5 (RANTES), which have also been implicated in various behavioral impairments including anxiety, depression, and LM [36-38].
Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection
A human CXCL8 analogue (G31P), antagonizes both CXCL1 and CXCL2, seems a promising agent in some models such as aspiration pneumoniae and ischemia-reperfusion injury [79, 80].
Future Directions and Molecular Basis of Ventilator Associated Pneumonia
(a-c) Plasma levels of CXCL1, MCP-1, and MIP-1[alpha] in treated mice (SkQ1 or MitoTEMPO) at 6, 24, 48, and 72 h post-CLP were compared to the placebo group (CLP + NaCl).
Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis
Moreover, CXCL1 and CXCL10 were key effectors on this malignant transformation [89].
Thyroid disorders: mechanisms and molecular characterization

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