CX3CR1


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CX3CR1

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for fractalkine, a transmembrane protein and chemokine involved in leukocyte adhesion and migration. CX3CR1 is also a coreceptor for HIV-1; some alternatively spliced forms of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS.
References in periodicals archive ?
The Weill Cornell researchers studied more than 500 Crohns disease patients and found that those who carry a homozygous mutation in the CX3CR1 gene have a reduced gut antifungal response, much like that seen in the mice lacking CX3CR1+ phagocytes.
We have also revealed by in vitro and in vivo studies that IRF8 promotes the transcription of P2X4R and the innate immune response toll-like receptor 2 (TLR2), chemokine receptor CX3CR1, interleukin-1[beta], cathepsin S, P2Y12R and BDNF that are involved in neuropathic pain.
These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).
The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma.
Fractalkine is an immune regulatory factor that sends signals via the CX3CR1 receptor, also called G-protein coupled receptor 13 (GPCR13).
In this study, we aimed to determine the CX3CR1 polymorphisms and their correlation with clinical findings in patients with UC.
3]C chemokine, which binds CX3CR1 on nearby cells will induce cell chemotaxis and survival (White and Greaves 2009).
Curcumin down-regulates CX3CR1 expression in spinal cord dorsal horn and DRG in neuropathic pain rats].
Isogeneic comparison of primary and metastatic lung cancer identifies CX3CR1 as a molecular determinant of site-specific metastatic diffusion.
Olefsky, MD, associate dean for scientific affairs and distinguished professor of medicine, and colleagues said that a transmembrane binding protein called fractalkine, which typically mediates cell-to-cell adhesion though its receptor, CX3CR1, can also be released from cells to circulate in the blood and stimulate insulin secretion.
A genomic analysis investigating the independent and combined effects ofCX3CR1 T280M and V249I, as well as CCR532 polymorphisms, on the efficacy of ART has been performed in a cohort of 461 western Canadian patients treated with 2 NRTIs, either with or without a PI No association was found between the presence CX3CR1 T280M or CCR532 alleles and response to ART.