CX3CR1


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CX3CR1

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for fractalkine, a transmembrane protein and chemokine involved in leukocyte adhesion and migration. CX3CR1 is also a coreceptor for HIV-1; some alternatively spliced forms of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS.
References in periodicals archive ?
Fractalkine is an immune regulatory factor that sends signals via the CX3CR1 receptor, also called G-protein coupled receptor 13 (GPCR13).
3]C chemokine, which binds CX3CR1 on nearby cells will induce cell chemotaxis and survival (White and Greaves 2009).
Curcumin down-regulates CX3CR1 expression in spinal cord dorsal horn and DRG in neuropathic pain rats].
Isogeneic comparison of primary and metastatic lung cancer identifies CX3CR1 as a molecular determinant of site-specific metastatic diffusion.
Olefsky, MD, associate dean for scientific affairs and distinguished professor of medicine, and colleagues said that a transmembrane binding protein called fractalkine, which typically mediates cell-to-cell adhesion though its receptor, CX3CR1, can also be released from cells to circulate in the blood and stimulate insulin secretion.
Opposite effects of CX3CR1 receptor polymorphisms V249I and T280M on the development of acute coronary syndrome.
A genomic analysis investigating the independent and combined effects ofCX3CR1 T280M and V249I, as well as CCR532 polymorphisms, on the efficacy of ART has been performed in a cohort of 461 western Canadian patients treated with 2 NRTIs, either with or without a PI No association was found between the presence CX3CR1 T280M or CCR532 alleles and response to ART.
Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge.
Gene polymorphisms in CCR5, CCR2, CX3CR1, SDF-1 and RANTES in exposed but uninfected partners of HIV-1 infected individuals in North India.
Finally, a possible consequence of the CCL3L1 production might be quantitative or qualitative changes in leukocyte recruitment, similarly to what recently reported for CX3CL1 and its receptor CX3CR1 (16).
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques.