P Protracted downregulation of CX3CR1
on microglia of aged mice after lipopolysaccharide challenge.
FKN induces inflammatory reaction by binding to the immune cells expressing FKN receptors (CX3CR1
Influence of polymorphisms within the CX3CR1
and MDR-1 genes on initial antiretroviral therapy response.
Correlation of CX3CL1 and CX3CR1
levels with response to infliximab therapy in patients with rheumatoid arthritis.
As CX3CL1 binds and signals through the CX3CR1
receptor, once this chemokine is released, it shows chemotaxis towards CX3CR1-expressing inflammatory cells, such as macrophages and T and NK cells, into the tissues (30).
Chemotaxis and adhesion are mediated by the G protein-coupled receptor CX3CR1
. Through both chemotactic and adhesive properties, CX3CL1 might have an important role in inflammation, and consequently, CX3CL1/CX3CR1 is involved in pathogenesis of various inflammatory disorders .
Murphy, "Chemokine receptor CX3CR1
mediates skin wound healing by promoting macrophage and fibroblast accumulation and function," Journal of Immunology, vol.
Hsu et al., "Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1
and CXCR4 and their engraftment in vivo," PLoS One, vol.
, a receptor for CX3CL1 (fractalkine) is expressed on [CD56.sup.dim][CD16.sup.+]; NK cells has been linked to NK cell migration to the brain in patients with multiple sclerosis .
Also, chemokine (C-X-C motif) receptor 4 (CXCR4) on monocytes responds to stromal cell-derived factor-1 (SDF-1) secreted by bone vascular endothelial and marrow stromal cells [24, 25], and CX3CR1
on monocytes responds to CX3CL1 secreted by osteoblasts .
Fractalkine (or CX3CL1) and its receptor (CX3CR1
) are also involved in this process .