CX3CR1


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CX3CR1

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for fractalkine, a transmembrane protein and chemokine involved in leukocyte adhesion and migration. CX3CR1 is also a coreceptor for HIV-1; some alternatively spliced forms of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS.
References in periodicals archive ?
Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response.
Correlation of CX3CL1 and CX3CR1 levels with response to infliximab therapy in patients with rheumatoid arthritis.
As CX3CL1 binds and signals through the CX3CR1 receptor, once this chemokine is released, it shows chemotaxis towards CX3CR1-expressing inflammatory cells, such as macrophages and T and NK cells, into the tissues (30).
Chemotaxis and adhesion are mediated by the G protein-coupled receptor CX3CR1. Through both chemotactic and adhesive properties, CX3CL1 might have an important role in inflammation, and consequently, CX3CL1/CX3CR1 is involved in pathogenesis of various inflammatory disorders [15].
Murphy, "Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function," Journal of Immunology, vol.
Hsu et al., "Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo," PLoS One, vol.
CX3CR1, a receptor for CX3CL1 (fractalkine) is expressed on [CD56.sup.dim][CD16.sup.+]; NK cells has been linked to NK cell migration to the brain in patients with multiple sclerosis [104].
Also, chemokine (C-X-C motif) receptor 4 (CXCR4) on monocytes responds to stromal cell-derived factor-1 (SDF-1) secreted by bone vascular endothelial and marrow stromal cells [24, 25], and CX3CR1 on monocytes responds to CX3CL1 secreted by osteoblasts [26].
Fractalkine (or CX3CL1) and its receptor (CX3CR1) are also involved in this process [24].