CX3CL1


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CX3CL1

A chemokine highly expressed in dendritic cells which is encoded by CX3CL1 on chromosome 16q13. CX3CL1 is thought to regulate leukocyte adhesion and migration in endothelium, given that membrane-bound CX3CL1 promotes adhesion of T cells and monocytes to endothelial cells.
References in periodicals archive ?
Seven ligands, CCL11, CCL17, CCL20, CCL22, XCL1, XCL2, and CX3CL1, were categorized as dual-function chemokines, which have both inflammatory and homeostatic functions.
Correlation of CX3CL1 and CX3CR1 levels with response to infliximab therapy in patients with rheumatoid arthritis.
In this study, we investigated the production of serum tumor necrosis factor (TNF), CX3CL1, and other physiological parameters in T.
To test whether the cytokines identified in the conditioned media mediated the bladder cancer cell migration, media containing the following selected recombinant factors: interleukin-8 (IL8) at 10ng/ml, chemokine (C-X-C motif) ligand 1 (CXCL1) at 10 ng/ml, plasminogen activator inhibitor 1 (PAI1) at 40 nM, interleukin6 (IL6) at 5ng/ml, fractalkine (CX3CL1) at 10ng/ml, and monocyte chemoattractant protein 1 (CCL2) at 1 ng/ml, was placed in the lower well of a Transwell system.
The expression of other Th1/Th17-related soluble factors (IL22, NFKB1, IL23A, STAT3, CCR5, IL17RA, CX3CL1, CXCL12, and CXCL5) was also assessed by RT-PCR, and the amount of mRNA calculated as above described.
CX3CR1, a receptor for CX3CL1 (fractalkine) is expressed on [CD56.sup.dim][CD16.sup.+]; NK cells has been linked to NK cell migration to the brain in patients with multiple sclerosis [104].
Also, chemokine (C-X-C motif) receptor 4 (CXCR4) on monocytes responds to stromal cell-derived factor-1 (SDF-1) secreted by bone vascular endothelial and marrow stromal cells [24, 25], and CX3CR1 on monocytes responds to CX3CL1 secreted by osteoblasts [26].
Fractalkine (or CX3CL1) and its receptor (CX3CR1) are also involved in this process [24].
Other reports showed that such effects were achieved through the induction of CX3CL1 as expressed at the choroid plexus.
Liu et al., "CX3CL1 up-regulation is associated with recruitment of [CX3CR1.sup.+] mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema," The American Journal of Pathology, vol.