CX3CL1


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CX3CL1

A chemokine highly expressed in dendritic cells which is encoded by CX3CL1 on chromosome 16q13. CX3CL1 is thought to regulate leukocyte adhesion and migration in endothelium, given that membrane-bound CX3CL1 promotes adhesion of T cells and monocytes to endothelial cells.
References in periodicals archive ?
The CX3CL1 is a chemokine released from neurons during the neuronal-to-microglial signaling (11).
Under inflamed conditions, the chemokine CX3CL1 (fractalkine) appears on lymphatic ECs and is actively secreted, and the soluble rather than membrane-anchored chemokine promotes DC migration toward lymphatics and EC transmigration.
2013) The chemo kine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics.
We showed that Tan IIA exhibits a strong antiatherosclerotic effect associated with reduced vascular cell adhesion molecule- (VCAM-) 1, intercellular adhesion molecule (ICAM-) 1, and CX3CL1 expression through inhibition of the NF-[kappa]B signaling pathway in human vascular endothelial cells [90].
The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-[alpha]-induced VCAM-1, ICAM-1 and CX3CL1 expression," Phytomedicine, vol.
PSORS 5 Crom 3 3q21 Cistatina A PSORS 6 Crom 19 19p JUNB PSORS 7 Crom 1 1 p PTPN22/IL23R PSORS 8 Crom 16 16q CX3CL1 PSORS 9 Crom 4 4q28-32 IL-15 PSORS 10 Crom 18 18p11 No descrito Regiones de Funcion susceptibilidad PSORS 1 Presentacion antigenica PSORS 2 Activacion persistente de LT PSORS 3 Inhibe competitivamente la activacion trans-cripcional mediada por IRF1 de IFN-[alpha] y [beta] PSORS 4 Complejo de diferenciacion epidermica PSORS 5 Propiedades bacteriostaticas en la piel PSORS 6 Regulacion de la actividad genetica PSORS 7 Receptor IL-23 PSORS 8 Quimiocina de LT y monocitos PSORS 9 Desarrollo y mantenimiento de celulas efectoras PSORS 10 18p11 Tabla 3.
On the other hand, a neuron-generated signaling chemical, or fractalkine, also called CX3CL1, suppresses the activation of microglia.
Finally, a possible consequence of the CCL3L1 production might be quantitative or qualitative changes in leukocyte recruitment, similarly to what recently reported for CX3CL1 and its receptor CX3CR1 (16).
Specifically, Zhang implicated CX3CL1 molecules as contributing to plaque build-up in the arteries.
Besides CTSG and TACR1, other genes down-regulated in the AR treatment group included CX3CL1, FZD1 and IGF2, associated proteins known to play a role in enhancing osteoclastogenesis (Xu et al.
The membrane-anchored CX3CL1, which is induced in activated endothelial cells, enables the integrin-independent capture and firm adhesion of leukocytes via the Gi coupled receptor CX3CR1.