GJA4

(redirected from CX37)

GJA4

A gene on chromosome 1p35.1 that encodes an alpha chain of the gap junction protein family or connexins.
 
Molecular pathology
GJA4 mutations are linked to atherosclerosis and an increased risk of myocardial infarction.
References in periodicals archive ?
different connexin types (Cx43, Cx40, Cx37) and are located at the
In atherosclerosis, expression of Cx37, Cx40, and Cx43 varies
The expression regions of Cx40, Cx37, and Cx43 are mainly restricted on the cytomembrane of vascular ECs [44].
Cxs expression (Cx37, Cx40, and Cx43) in the venous system also exhibited the same manner as in the arterial systems, which is a regional variation [50].
RT-qPCR Analysis of Cx36, Cx37, Cx40, Cx43, LHR, FSHR, and CYP19A1 mRNA Expression in GCs.
Using an RT-qPCR assay, we analyzed the relative abundance of Cx36, Cx37, Cx40, Cx43, LHR, FSHR, and CYP19 mRNA after each period of GC real-time proliferation in vitro.
To date, at least 15 connexin genes have been reported in mammals, and seven genes (Cx26, Cx30, Cx32, Cx37, Cx43, Cx45, and Cx60) are expressed in the ovary.
Resting monocytes express Cx37 and, after activation, they also express Cx43.
Peritoneal, alveolar, and cell lines derived from macrophage express Cx37 and Cx43 under resting conditions, and upregulation of Cx43 expression is observed after activation [55, 72, 94, 144, 147, 149-155].
Among connexin (Cx) proteins, Cx43 and Cx37 play an important role in ovarian folliculogenesis (Grazul-Bilska et al., 1997).
[5] Human genes: ESR1, estrogen receptor 1 (formerly ESR); ESR2, estrogen receptor 2 (ER R); KCNHS, potassium voltage-gated channel, subfamily H (eag-related), member 5; GJA4, gap junction protein, [alpha]4, 37 kDa (formerly CX37).
To evaluate the expression of Cx26, Cx32, Cx37 and Cx43 during the periovulatory period, ovaries were collected from ewes (n = 5-7/group) injected twice daily with follicle stimulating hormone (FSH) on days 13 and 14 of the estrous cycle, and with FSH and human chorionic gonadotropin (hCG; ovulatory dose) on the morning of day 15 of the estrous cycle.