GJD2

(redirected from CX36)

GJD2

A gene on chromosome 15q14 that encodes a delta chain of the gap junction protein family or connexins.
Mentioned in ?
References in periodicals archive ?
Cx36, together with a site-specific expression of Cx45 and Cx57, is the principal connexin expressed in neurons.
In an ultrasound-induced BBB opening Wistar rat model [71], reorganization of neuronal Cx36-containing GJs with an increase in gap-junctional plaque size was found, similar to the results in another study [72]; neuronal Cx36 interacts with a ZO-1 PDZ domain, the same as in astrocytic Cx43, thus indicating that ultrasound-induced disruption of ZO-1 might lead to an increase in Cx36 plaque size.
(2004) Potent block of Cx36 and Cx50 gap junction channels by mefloquine.
Kamasawa et al., "Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb," Journal of Neurocytology, vol.
Pancreatic [beta]-cells solely express Cx36 and are therefore hypothesized to be unaffected by JM2, as opposed to pan-connexin channel blockers that could potentially affect insulin production [41].
Due to its importance in the insulin secretion process, we also investigated proteins related to calcium ([Ca.sup.2+]) influx, such as protein kinase C (PKC) and connexin 36 (CX36).
Cx32, Cx36, and Cx43 have been detected in cultured microglia [23, 24, 26-28].
Connexin 36 (Cx36) is a transmembrane protein that forms gap junctions for [beta]-cells communication [27-31].
The most common isoforms in mammals are Cx36, Cx43,and Cx45.
Microglia express low to undetectable levels of Cx32, Cx36, Cx43, and Cx45 [136-139].
This feature is shared by another [gamma] connexin, mouse Cx36 (data not shown), and illustrates further the unique properties of this su bgroup.