Cx36, together with a site-specific expression of Cx45 and Cx57, is the principal connexin expressed in neurons.
In an ultrasound-induced BBB opening Wistar rat model , reorganization of neuronal Cx36-containing GJs with an increase in gap-junctional plaque size was found, similar to the results in another study ; neuronal Cx36 interacts with a ZO-1 PDZ domain, the same as in astrocytic Cx43, thus indicating that ultrasound-induced disruption of ZO-1 might lead to an increase in Cx36 plaque size.
(2004) Potent block of Cx36
and Cx50 gap junction channels by mefloquine.
Kamasawa et al., "Ultrastructural localization of connexins (Cx36
, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb," Journal of Neurocytology, vol.
RT-qPCR Analysis of Cx36
, Cx37, Cx40, Cx43, LHR, FSHR, and CYP19A1 mRNA Expression in GCs.
Pancreatic [beta]-cells solely express Cx36
and are therefore hypothesized to be unaffected by JM2, as opposed to pan-connexin channel blockers that could potentially affect insulin production .
Due to its importance in the insulin secretion process, we also investigated proteins related to calcium ([Ca.sup.2+]) influx, such as protein kinase C (PKC) and connexin 36 (CX36
, and Cx43 have been detected in cultured microglia [23, 24, 26-28].
Connexin 36 (Cx36
) is a transmembrane protein that forms gap junctions for [beta]-cells communication [27-31].
The most common isoforms in mammals are Cx36
, Cx43,and Cx45.
Microglia express low to undetectable levels of Cx32, Cx36
, Cx43, and Cx45 [136-139].
This feature is shared by another [gamma] connexin, mouse Cx36
(data not shown), and illustrates further the unique properties of this su bgroup.