GJD2

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GJD2

A gene on chromosome 15q14 that encodes a delta chain of the gap junction protein family or connexins.
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Cx36, together with a site-specific expression of Cx45 and Cx57, is the principal connexin expressed in neurons.
In an ultrasound-induced BBB opening Wistar rat model [71], reorganization of neuronal Cx36-containing GJs with an increase in gap-junctional plaque size was found, similar to the results in another study [72]; neuronal Cx36 interacts with a ZO-1 PDZ domain, the same as in astrocytic Cx43, thus indicating that ultrasound-induced disruption of ZO-1 might lead to an increase in Cx36 plaque size.
Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases
(2004) Potent block of Cx36 and Cx50 gap junction channels by mefloquine.
Rapid and coordinated processing of global motion images by local clusters of retinal ganglion cells
Kamasawa et al., "Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb," Journal of Neurocytology, vol.
miRNA Expression Profile and Effect of Wenxin Granule in Rats with Ligation-Induced Myocardial Infarction
RT-qPCR Analysis of Cx36, Cx37, Cx40, Cx43, LHR, FSHR, and CYP19A1 mRNA Expression in GCs.
Time- and Dose-Dependent Effects of 17 Beta-Estradiol on Short-Term, Real-Time Proliferation and Gene Expression in Porcine Granulosa Cells
Pancreatic [beta]-cells solely express Cx36 and are therefore hypothesized to be unaffected by JM2, as opposed to pan-connexin channel blockers that could potentially affect insulin production [41].
Connexin-based therapeutics and tissue engineering approaches to the amelioration of chronic pancreatitis and type I diabetes: construction and characterization of a novel prevascularized bioartificial pancreas
Due to its importance in the insulin secretion process, we also investigated proteins related to calcium ([Ca.sup.2+]) influx, such as protein kinase C (PKC) and connexin 36 (CX36).
Augmented [beta]-cell function and mass in glucocorticoid-treated rodents are associated with increased islet Ir-[beta]/AKT/mTOR and decreased AMPK/ACC and AS160 signaling
Cx32, Cx36, and Cx43 have been detected in cultured microglia [23, 24, 26-28].
ATP is required and advances cytokine-induced gap junction formation in microglia in vitro
Connexin 36 (Cx36) is a transmembrane protein that forms gap junctions for [beta]-cells communication [27-31].
Decompensation of [beta]-cells in diabetes: when pancreatic [beta]-cells are on ICE(R)
The most common isoforms in mammals are Cx36, Cx43,and Cx45.
Microglia: an active player in the regulation of synaptic activity
Microglia express low to undetectable levels of Cx32, Cx36, Cx43, and Cx45 [136-139].
Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation
This feature is shared by another [gamma] connexin, mouse Cx36 (data not shown), and illustrates further the unique properties of this su bgroup.
Voltage Gating Properties of Channels Formed by a Skate Retinal Connexin

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