GJD3

(redirected from CX31.9)

GJD3

A gene on chromosome 17q21.2 that encodes a delta chain of the gap junction protein family or connexins.
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Gja5 (Cx40) and Gjd3 (Cx31.9) were downregulated in GK compared to control SAN.
For example, Gja5 (Cx40) and Gjd3 (Cx31.9) were downregulated in GK and unaltered in STZ SAN; Trpc6 (TRPC6) was downregulated in GK and upregulated in STZ SAN; Ryr2 (RYR2) was upregulated in GK and unaltered in STZ SAN; Hcn1 (HCN1) and Hcn4 (HCN4) were downregulated in GK and unaltered in STZ SAN; Cacna1d ([Ca.sub.v]1.3), Cacna1h (Cav3.2), and Cacng4 ([Cav.sub.[gamma]]4) were downregulated in GK SAN; however, in the STZ study, Cacna1d was unaltered, Cacna1h was upregulated, and Cacng4 was downregulated; Kcna5 ([K.sub.v]1.5) and Kcnk1 (TWIK1) were downregulated in GK SAN and unaltered in STZ SAN; Nppb (BNP) was upregulated in GK and in STZ SAN.