CUX2

CUX2

A gene on chromosome 7q22.1 that encodes a member of the homeodomain family of DNA binding proteins that may play a role in neural specification during development.
References in periodicals archive ?
Downstream of STAT5 is a major cascade of sex-specific regulated gene expression of 500-1000 genes (including other transcription repressors such as BCL6; transcription activators such as Cux2, HNF4[alpha], HNF6,
Cux2 and Cux2+ excitatory progenitors, respectively, generate distinct subtypes of upperlayer and deep-layer neurons.
Using the publically available results consisting of 74 nominally significant CpGs, we find confirmation of 9 CpGs in 8 gene regions (GNG12, LOC284998, VGLL4, FRMD4A, CUX2, MEG3, FTO, and ATP9A).
In contrast, of 17 established gene regions identified in both newborn studies, 6 were reported in at least one adult study (AHRR, CNTNAP2, GNG12, GFI1, ATP9A, MYO1G), whereas 11 (LOC284998, FTO, CUX2, CYP1A1, VGLL4, KIF26B, MEG3, FRMD4A, GALNT2, LOC100507468, EXT1) were restricted to newborns only.
The team followed a marker gene called Cux2, which was previously reported to be expressed only by upper-layer neurons.
Surprisingly, the team observed Cux2 already turned on in some of the RGCs, even at the earliest points in brain development--embryonic day nine or ten--before any upper-layer neurons exist.