CUL1A gene on chromosome 7q36.1 that encodes cullin-1, a component of the multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Cullin-1 is thought to contribute to catalysis by positioning the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex depends on the neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.