CUL3

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CUL3

A gene on chromosome 2q36.2 that encodes cullin-3, a core protein of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin-3 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The ubiquitin-protein ligase activity of the complex depends on neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.
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Tenders are invited for Spl Repair To Bldg Nos D-4 To D-8 Of Cul-4, Or Living Accn Sup T-44 And T-45 Of Cul-3 At North Camp At Age Mffr Under Ge (N) Bikaner