PPBP

(redirected from CTAPIII)

PPBP

A gene on chromosome 4q12-q13 that encodes a platelet-derived growth factor of the CXC chemokine family, which is a potent chemoattractant and activator of neutrophils. PPBP drives various cellular processes, including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
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The levels of the fourth novel marker, connective tissue-activating peptide III (CTAPIII), were lower in more severe stages of OA (Kellgren and Lawrence grades 3 and 4) but higher in both sets of control subjects, and were correlated to markers of inflammation, suggesting that this marker might reflect a proinflammatory pathway, according to Dr.
The levels of the fourth novel marker, connective tissue-activating peptide III (CTAPIII), were lower in more severe stages of OA (Kellgren & Lawrence grades 3 and 4) but higher in both sets of control subjects, and were correlated to markers of inflammation, suggesting that this marker reflects a proinflammatory pathway, according to Dr.