PPBP

(redirected from CTAP3)

PPBP

A gene on chromosome 4q12-q13 that encodes a platelet-derived growth factor of the CXC chemokine family, which is a potent chemoattractant and activator of neutrophils. PPBP drives various cellular processes, including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
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None of our individual biomarker candidates [the final 7 SELDI marker candidates were ITIH4 (inter-[alpha]-trypsin inhibitor heavy chain 4), transthyretin, apolipoprotein A1, hepcidin, [[beta].sub.2]-microglobulin, transferrin, and CTAP3 (connective tissue-activating peptide III), in addition to CA125] were exciting, and indeed some tasters dismissed them as being nonspecific.
[2] Nonstandard abbreviations: CA125, cancer antigen 125; ITIH4, inter-[alpha]-trypsin inhibitor heavy chain 4; CTAP3, connective tissue-activating peptide III; FDA, US Food and Drug Administration; IDE, investigational device exemption.